文章目录[隐藏]
TFRC 分子靶点信息概述
- 分子名:TFRC, transferrin receptor
- 基因家族:CD molecules; M28 metallopeptidases
- 别名:CD71; TFR1; p90
- 全称:transferrin receptor (p90, CD71)
TFRC 分子靶点综述
转铁蛋白受体 CD71 是一种 1180 kDa 的 II 型跨膜蛋白,在细胞表面以同源二聚体的形式存在,对细胞生长至关重要。CD71 表达于未成熟的增殖中的细胞,在静息的成熟淋巴细胞中表达水平较低。抗原或丝裂原刺激的 T 细胞和 B 细胞可上调 CD71 的表达。
TFRC, transferrin receptor 分子靶点种属信息
人 Human TFRC 分子靶点信息
- 分子名:TFRC, transferrin receptor
- 别称:
- CD71
- IMD46
- p90
- T9
- TFR
- TFR1
- TR
- transferrin receptor (p90, CD71)
- transferrin receptor protein 1
- TRFR
- 基因序列:NCBI_Gene: 7037
- 蛋白序列:UniProtKB: P02786
人 Human TFRC靶点分子功能(预测)
Enables several functions, including double-stranded RNA binding activity; protein homodimerization activity; and transferrin receptor activity. Involved in several processes, including negative regulation of mitochondrial fusion; positive regulation of NF-kappaB transcription factor activity; and positive regulation of lymphocyte activation. Acts upstream of or within cellular response to xenobiotic stimulus. Located in several cellular components, including basolateral plasma membrane; clathrin-coated pit; and endosome. Is integral component of plasma membrane. Part of HFE-transferrin receptor complex. Implicated in breast carcinoma; immunodeficiency 46; multiple myeloma; and ovarian cancer. Biomarker of breast cancer; carcinoma (multiple); iron deficiency anemia; and prostate cancer.
小鼠 Mouse Tfrc 分子靶点信息
- 分子名:Tfrc, transferrin receptor
- 别称:
- 2610028K12Rik
- AI195355
- AI426448
- AU015758
- CD71
- E430033M20Rik
- expressed sequence AI195355
- expressed sequence AI426448
- expressed sequence AU015758
- mammary tumor virus receptor 1
- Mtvr-1
- Mtvr1
- p90
- RIKEN cDNA 2610028K12 gene
- RIKEN cDNA E430033M20 gene
- TfR1
- Trfr
- 基因序列:NCBI_Gene: 22042
- 蛋白序列:
小鼠 Mouse Tfrc 靶点分子功能(预测)
Predicted to enable several functions, including Hsp70 protein binding activity; chaperone binding activity; and protein homodimerization activity. Involved in osteoclast differentiation; positive regulation of bone resorption; and positive regulation of lymphocyte proliferation. Acts upstream of or within cellular iron ion homeostasis and cellular response to leukemia inhibitory factor. Located in several cellular components, including clathrin-coated pit; endosome; and extracellular exosome. Part of HFE-transferrin receptor complex. Is expressed in several structures, including alimentary system; extraembryonic component; liver; lung; and meninges. Human ortholog(s) of this gene implicated in breast carcinoma; immunodeficiency 46; multiple myeloma; and ovarian cancer. Orthologous to human TFRC (transferrin receptor).
大鼠 Rat Tfrc 分子靶点信息
- 分子名:Tfrc, transferrin receptor
- 别称:
- tfR
- tfR1
- TR
- transferrin receptor protein 1
- Trfr
- 基因序列:NCBI_Gene: 64678
- 蛋白序列:
大鼠 Rat Tfrc 靶点分子功能(预测)
Enables Hsp70 protein binding activity; chaperone binding activity; and transferrin receptor activity. Involved in several processes, including response to copper ion; response to manganese ion; and response to retinoic acid. Located in several cellular components, including cell surface; extracellular exosome; and recycling endosome membrane. Biomarker of duodenal ulcer; hepatocellular carcinoma; muscular atrophy; non-alcoholic fatty liver disease; and nutrition disease. Human ortholog(s) of this gene implicated in breast carcinoma; immunodeficiency 46; multiple myeloma; and ovarian cancer. Orthologous to human TFRC (transferrin receptor).
TFRC 分子产品列表
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- F1107101
- 流式抗体(新品), 流式抗体
Anti-Human CD71, FITC(Clone:OKT9) (新品)
- ¥872.00 – ¥1,936.00
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- EK1146
- ELISA试剂盒
Human Transferrin Receptor/TFR ELISA Kit检测试剂盒(酶联免疫吸附法)
- ¥1,600.00 – ¥2,650.00