PDGFB 靶点信息

PDGFB 分子靶点信息概述

  • 分子名：PDGFB, platelet derived growth factor subunit B
  • 别名：SSV
  • 曾用名：SIS
  • 全称：oncogene SIS; becaplermin; platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog); platelet-derived growth factor beta polypeptide

PDGFB 分子靶点综述

血小板衍生因子(PDGF)是众多调节细胞生长和分裂的因子之一。从化学结构上来说，PDGF是一种由两条A链(-AA)或两条B链(-BB)或AB链组合(-AB)形成的二聚体糖蛋白。特别是，它在血管生成、已存在的血管组织生长中起着重要作用。不受控制的血管生成是肿瘤的一个特征。肝细胞和不吸收的破骨细胞表达PDGF-BB，产生成骨细胞和骨头，血小板、巨噬细胞和肥大细胞也能产生PDGF-BB。在损伤部位，PDGF-BB促进中性粒细胞和巨噬细胞浸润，发挥清创作用，促进成纤维细胞分泌新的细胞外基质，促进IGF-1介导再上皮化。

PDGFB, platelet derived growth factor subunit B 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human PDGFB 分子靶点信息

  • 分子名：PDGFB, platelet derived growth factor subunit B
  • 别称：
    • becaplermin
    • c-sis
    • FLJ12858
    • IBGC5
    • PDGF subunit B
    • PDGF-2
    • PDGF, B chain
    • PDGF2
    • platelet-derived growth factor 2
    • platelet-derived growth factor B chain
    • platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)
    • platelet-derived growth factor subunit B
    • platelet-derived growth factor, B chain
    • Platelet-derived growth factor, beta polypeptide (oncogene SIS)
    • proto-oncogene c-Sis
    • SIS
    • SSV
  • 基因序列：NCBI_Gene: 5155
  • 蛋白序列：UniProtKB: P01127

人 Human PDGFB靶点分子功能（预测）

Enables several functions, including platelet-derived growth factor binding activity; protein dimerization activity; and receptor ligand activity. Involved in several processes, including positive regulation of cell migration; positive regulation of cell population proliferation; and positive regulation of phosphorylation. Located in cell surface. Implicated in basal ganglia calcification; clear cell renal cell carcinoma; connective tissue cancer (multiple); familial meningioma; and prostatic hypertrophy. Biomarker of several diseases, including Kuhnt-Junius degeneration; bone disease (multiple); clear cell renal cell carcinoma; diabetic retinopathy (multiple); and reproductive organ cancer (multiple).

小鼠 Mouse Pdgfb 分子靶点信息

小鼠 Mouse Pdgfb 靶点分子功能（预测）

Predicted to enable several functions, including platelet-derived growth factor binding activity; protein dimerization activity; and receptor ligand activity. Involved in several processes, including metanephric glomerular mesangium development; paracrine signaling; and positive regulation of glomerular filtration. Acts upstream of or within several processes, including animal organ development; nervous system development; and regulation of cell migration. Predicted to be located in several cellular components, including basolateral plasma membrane; dendrite; and neuronal cell body. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; cardiovascular system; extraembryonic component; female reproductive system; and nervous system. Human ortholog(s) of this gene implicated in basal ganglia calcification; clear cell renal cell carcinoma; connective tissue cancer (multiple); familial meningioma; and prostatic hypertrophy. Orthologous to human PDGFB (platelet derived growth factor subunit B).

大鼠 Rat Pdgfb 分子靶点信息

  • 分子名：Pdgfb, platelet derived growth factor subunit B
  • 别称：
    • c-sis
    • pdgf protein
    • PDGF subunit B
    • PDGF-2
    • platelet derived growth factor-bb
    • platelet derived growth factor, B polypeptide
    • Platelet-derived growth factor
    • platelet-derived growth factor B chain
    • platelet-derived growth factor beta polypeptide
    • platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)
    • Platelet-derived growth factor same as Sis (Simian sarcoma viral oncogene homologue c-sis)
    • platelet-derived growth factor subunit B
    • Platelet-derived growth factor, same as Sis (Simian sarcoma viral oncogene homologue, c-sis)
    • SIS
  • 基因序列：NCBI_Gene: 24628
  • 蛋白序列：

大鼠 Rat Pdgfb 靶点分子功能（预测）

Enables signaling receptor binding activity. Involved in several processes, including positive regulation of biosynthetic process; positive regulation of cell migration; and response to peptide hormone. Located in several cellular components, including basolateral plasma membrane; dendrite; and neuronal cell body. Used to study asthma; brain infarction; glomerulonephritis; and visual epilepsy. Biomarker of cholestasis; hypertension (multiple); liver cirrhosis; oligohydramnios; and ureteral obstruction. Human ortholog(s) of this gene implicated in basal ganglia calcification; clear cell renal cell carcinoma; connective tissue cancer (multiple); familial meningioma; and prostatic hypertrophy. Orthologous to human PDGFB (platelet derived growth factor subunit B).

PDGFB 分子产品列表

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