MICA 分子靶点信息概述

  • 分子名:MICA, MHC class I polypeptide-related sequence A
  • 基因家族:C1-set domain containing
  • 别名:PERB11.1

MICA 分子靶点综述

MHC I 类多肽相关序列 A 是一种在人类中由 MICA 基因编码的蛋白质。MICA 在正常细胞上表达最少,但常在上皮肿瘤上表达或脱落,可被细菌和病毒感染诱导。近年来针对以 MICA 为代表的 NKG2D 受体激活通路及其两者之间的相互调节机制在肿瘤免疫、自身免疫和抗感染免疫等研究领域得到了广泛关注。这种膜蛋白分子能与 NK 细胞表面上的NKG2D 受体结合,从而激活 NK 细胞的杀伤活性。MICA 的识别涉及到肿瘤监测、病毒感染和自身免疫疾病。 MICA基因的分布特征与地域、人群等因素有关,不同人群之间等位基因分布频率存在差异。

MICA, MHC class I polypeptide-related sequence A 分子靶点种属信息

人 Human

人 Human MICA 分子靶点信息

  • 分子名:MICA, MHC class I polypeptide-related sequence A
  • 别称:
    • FLJ36918
    • FLJ60820
    • HLA class I antigen
    • major histocompatibility complex class I chain-related protein A
    • MGC111087
    • MGC21250
    • MHC class I chain-related gene A protein
    • MHC class I chain-related protein A
    • MHC class I related chain A
    • MHC class I related sequence A
    • MIC-A
    • PERB11.1
    • Stress inducible class I homolog
    • truncated MHC class I polypeptide-related sequence A
    • truncated MICA
  • 基因序列:NCBI_Gene: 100507436
  • 蛋白序列:UniProtKB: Q29983

人 Human MICB靶点分子功能(预测)

Enables natural killer cell lectin-like receptor binding activity. Involved in several processes, including T cell mediated cytotoxicity; defense response to other organism; and negative regulation of natural killer cell mediated cytotoxicity. Located in cell surface and extracellular space. Is integral component of plasma membrane.

MICA 分子产品列表

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