文章目录[隐藏]
MICA 分子靶点信息概述
- 分子名：MICA, MHC class I polypeptide-related sequence A
- 基因家族：C1-set domain containing
- 别名：PERB11.1
MICA 分子靶点综述
MHC I 类多肽相关序列 A 是一种在人类中由 MICA 基因编码的蛋白质。MICA 在正常细胞上表达最少，但常在上皮肿瘤上表达或脱落，可被细菌和病毒感染诱导。近年来针对以 MICA 为代表的 NKG2D 受体激活通路及其两者之间的相互调节机制在肿瘤免疫、自身免疫和抗感染免疫等研究领域得到了广泛关注。这种膜蛋白分子能与 NK 细胞表面上的NKG2D 受体结合，从而激活 NK 细胞的杀伤活性。MICA 的识别涉及到肿瘤监测、病毒感染和自身免疫疾病。 MICA基因的分布特征与地域、人群等因素有关，不同人群之间等位基因分布频率存在差异。
MICA, MHC class I polypeptide-related sequence A 分子靶点种属信息
人 Human
人 Human MICA 分子靶点信息
- 分子名：MICA, MHC class I polypeptide-related sequence A
- 别称：
- FLJ36918
- FLJ60820
- HLA class I antigen
- major histocompatibility complex class I chain-related protein A
- MGC111087
- MGC21250
- MHC class I chain-related gene A protein
- MHC class I chain-related protein A
- MHC class I related chain A
- MHC class I related sequence A
- MIC-A
- PERB11.1
- Stress inducible class I homolog
- truncated MHC class I polypeptide-related sequence A
- truncated MICA
- 基因序列：NCBI_Gene: 100507436
- 蛋白序列：UniProtKB: Q29983
人 Human MICB靶点分子功能（预测）
Enables natural killer cell lectin-like receptor binding activity. Involved in several processes, including T cell mediated cytotoxicity; defense response to other organism; and negative regulation of natural killer cell mediated cytotoxicity. Located in cell surface and extracellular space. Is integral component of plasma membrane.
