IL11 分子靶点信息概述

  • 分子名:IL11, interleukin 11
  • 基因家族:Interleukins; Interleukin 6 type cytokine family
  • 别名:IL-11; AGIF
  • 全称:adipogenesis inhibitory factor; oprelvekin

IL11 分子靶点综述

白细胞介素 11 (IL-11)是一个多功能细胞因子,早在 1990 年就从骨髓间充质干细胞中分离而 来。它是 IL-6 型细胞因子家族中的一员,可根据他们使用的共受体 gp130 来区分。IL-11 在造血调 控中起着重要调节作用,尤其是刺激巨核细胞的成熟。研究证实,IL-11 可改善由化疗引起的血小 板减少症、诱导急性期蛋白、调节抗原-抗体应答、参与调控骨细胞的增殖和分化。IL-11 引起骨 吸收,还可刺激某些淋巴细胞的生长,在小鼠模型中,刺激长骨皮质厚度和强度的增加。作为一 种信号分子,IL-11 具有多种功能,包括胎盘形成和某种程度上的蜕膜化,在胚泡植入子宫内膜的 过程中有一定的作用。IL-11 是利用重组 DNA 技术合成的,在市面上被称为奥普瑞白介素,用来 防治癌症患者严重的血小板减少症。

IL11, interleukin 11 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human IL11 分子靶点信息

  • 分子名:IL11, interleukin 11
  • 别称:
    • adipogenesis inhibitory factor
    • AGIF
    • IL-11
    • interleukin-11
    • oprelvekin
  • 基因序列:NCBI_Gene: 3589
  • 蛋白序列:UniProtKB: P20809

人 Human IL11靶点分子功能(预测)

Enables growth factor activity. Involved in positive regulation of cell population proliferation. Acts upstream of or within several processes, including negative regulation of hormone secretion; positive regulation of MAPK cascade; and positive regulation of protein phosphorylation. Predicted to be located in extracellular region. Predicted to be active in cytoplasm.

小鼠 Mouse Il11 分子靶点信息

小鼠 Mouse Il11 靶点分子功能(预测)

Enables cytokine activity and interleukin-11 receptor binding activity. Acts upstream of or within positive regulation of cell population proliferation. Located in cytoplasm. Orthologous to human IL11 (interleukin 11).

大鼠 Rat Il11 分子靶点信息

大鼠 Rat Il11 靶点分子功能(预测)

Predicted to enable cytokine activity; growth factor activity; and interleukin-11 receptor binding activity. Predicted to be involved in positive regulation of MAPK cascade and positive regulation of cell population proliferation. Predicted to act upstream of or within negative regulation of hormone secretion; positive regulation of protein phosphorylation; and positive regulation of transcription by RNA polymerase II. Predicted to be located in extracellular space. Predicted to be active in cytoplasm. Orthologous to human IL11 (interleukin 11).

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