文章目录[隐藏]
- IGFBP3 分子靶点信息概述
- IGFBP3 分子靶点综述
- IGFBP3, insulin like growth factor binding protein 3 分子靶点种属信息
- IGFBP3 分子产品列表
- Mouse IGFBP-3 Standard (小鼠胰岛素样生长因子结合蛋白3 (IGFBP-3) 标准品)
- Mouse IGFBP-3 ELISA Kit检测试剂盒(酶联免疫吸附法)
- Human IGFBP-3 ELISA Kit检测试剂盒(酶联免疫吸附法)
- Human IGFBP-3 Standard (人胰岛素样生长因子结合蛋白3 (IGFBP-3) 标准品)
- IGFBP3 分子靶点最新资讯
IGFBP3 分子靶点信息概述
- 分子名:IGFBP3, insulin like growth factor binding protein 3
- 基因家族:Insulin like growth factor binding proteins
- 别名:IBP3; BP-53
- 全称:growth hormone-dependent binding protein; acid stable subunit of the 140 K IGF complex; binding protein 53; binding protein 29; IGF-binding protein 3; insulin-like growth factor binding protein 3
IGFBP3 分子靶点综述
胰岛素样生长因子结合蛋白3(IGFBP-3),在人类中由IGFBP3基因编码。IGFBP-3是六个IGF结合蛋白(IGFBP-1至6)中的一个,这些结合蛋白具有高度保守结构,并可高亲和力结合IGF-1和IGF-2。IGFBP-3是血液中IGF的主要转运蛋白。它与细胞表面蛋白相互作用,影响胞外或内化后的细胞信号,它也可进入细胞核,在这里,它结合核激素受体和其它配体。基于细胞生长实验、动物癌症模型和流行病学研究,IGFBP-3似乎可作为低外显率的肿瘤抑制基因。失调的IGFBP-3参与许多癌症。血清中IGFBP-3水平可用来筛选生长激素是否缺乏。在AIDS、不受控制的糖尿病、创伤和严重烧伤患者的血清中,IGFBP-3水平是下降的。
IGFBP3, insulin like growth factor binding protein 3 分子靶点种属信息
人 Human IGFBP3 分子靶点信息
- 分子名:IGFBP3, insulin like growth factor binding protein 3
- 别称:
- acid stable subunit of the 140 K IGF complex
- binding protein 29
- binding protein 53
- BP-53
- growth hormone-dependent binding protein
- IBP-3
- IBP3
- IGF-binding protein 3
- IGFBP-3
- insulin-like growth factor binding protein 3
- insulin-like growth factor-binding protein 3
- 基因序列:NCBI_Gene: 3486
- 蛋白序列:UniProtKB: P17936
人 Human IGFBP3靶点分子功能(预测)
Enables insulin-like growth factor I binding activity and protein tyrosine phosphatase activator activity. Involved in several processes, including negative regulation of smooth muscle cell migration; negative regulation of smooth muscle cell proliferation; and positive regulation of myoblast differentiation. Acts upstream of or within negative regulation of cell population proliferation; negative regulation of protein phosphorylation; and protein phosphorylation. Located in extracellular space and nucleus. Part of insulin-like growth factor ternary complex. Implicated in several diseases, including Alzheimer's disease; Turner syndrome; diabetes mellitus (multiple); prostate cancer; and transitional cell carcinoma. Biomarker of several diseases, including Barrett's esophagus; Down syndrome; autoimmune disease (multiple); bone disease (multiple); and urinary system cancer (multiple).
小鼠 Mouse Igfbp3 分子靶点信息
- 分子名:Igfbp3, insulin-like growth factor binding protein 3
- 别称:
- AI649005
- expressed sequence AI649005
- IGFBP-3
- 基因序列:NCBI_Gene: 16009
- 蛋白序列:
小鼠 Mouse Igfbp3 靶点分子功能(预测)
Enables fibronectin binding activity and insulin-like growth factor binding activity. Acts upstream of or within several processes, including osteoblast differentiation; positive regulation of signal transduction; and type B pancreatic cell proliferation. Located in extracellular space. Is expressed in several structures, including alimentary system; brain; early embryo; gonad; and limb. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Turner syndrome; diabetes mellitus (multiple); prostate cancer; and transitional cell carcinoma. Orthologous to human IGFBP3 (insulin like growth factor binding protein 3).
大鼠 Rat Igfbp3 分子靶点信息
- 分子名:Igfbp3, insulin-like growth factor binding protein 3
- 别称:
- IBP-3
- IGF-binding protein 3
- IGF-BP3
- IGFBP-3
- Insulin-like growth factor-binding protein (IGF-BP3)
- insulin-like growth factor-binding protein 3
- MGC156773
- 基因序列:NCBI_Gene: 24484
- 蛋白序列:
大鼠 Rat Igfbp3 靶点分子功能(预测)
Enables insulin-like growth factor II binding activity. Involved in several processes, including cellular response to Thyroglobulin triiodothyronine; cellular response to estradiol stimulus; and response to peptide hormone. Located in extracellular space; heterochromatin; and platelet alpha granule. Part of insulin-like growth factor binary complex and insulin-like growth factor ternary complex. Used to study impotence. Biomarker of congenital diaphragmatic hernia; impotence; and obesity. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Turner syndrome; diabetes mellitus (multiple); prostate cancer; and transitional cell carcinoma. Orthologous to human IGFBP3 (insulin like growth factor binding protein 3).
IGFBP3 分子产品列表
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- EK2168
- ELISA试剂盒
Mouse IGFBP-3 ELISA Kit检测试剂盒(酶联免疫吸附法)
- ¥2,000.00 – ¥3,400.00
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- EK1168
- ELISA试剂盒
Human IGFBP-3 ELISA Kit检测试剂盒(酶联免疫吸附法)
- ¥1,600.00 – ¥2,650.00