IFNGR1 靶点信息

IFNGR1 分子靶点信息概述

  • 分子名：IFNGR1, interferon gamma receptor 1
  • 基因家族：Interferon receptors; CD molecules
  • 别名：CD119
  • 曾用名：IFNGR

IFNGR1 分子靶点综述

分化簇（CD）系统是免疫表型分析中常用的细胞标记体系，通过细胞表面与免疫功能相关的CD分子可鉴别免疫系统中不同种类的细胞。目前已有超过320种独特的CD分子及其亚群被鉴定。部分CD分子作为受体或配体，通过启动信号级联反应改变细胞行为；另一些CD蛋白虽不参与细胞信号传导，但具有细胞粘附等其他功能。
CD119（分化簇119），又称干扰素γ受体1（IFNGR1），是异源二聚体γ干扰素受体的组成部分。该受体由配体结合链IFNGR1（CD119）和非配体结合链IFNGR2构成：IFNGR1基因编码受体α链（配体结合亚基），而IFNGR2基因编码辅助亚基。干扰素γ的生物活性需通过与其受体CD119结合来实现。当干扰素γ与CD119结合后，由活化T淋巴细胞产生的这种细胞因子可对多种细胞类型发挥三重生物学效应：抗病毒活性；生长抑制作用；广泛的免疫调节功能。

IFNGR1, interferon gamma receptor 1 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human IFNGR1 分子靶点信息

  • 分子名：IFNGR1, interferon gamma receptor 1
  • 别称：
    • antiviral protein, type 2
    • AVP, type 2
    • CD119
    • CD119 antigen
    • CDw119
    • FLJ45734
    • IFN-gamma receptor 1
    • IFN-gamma-R-alpha
    • IFN-gamma-R1
    • IFNGR
    • IMD27A
    • IMD27B
    • immune interferon receptor 1
    • interferon-gamma receptor alpha chain
  • 基因序列：NCBI_Gene: 3459
  • 蛋白序列：UniProtKB: P15260

人 Human IFNGR1 靶点分子功能（预测）

Enables type II interferon receptor activity. Involved in type II interferon-mediated signaling pathway and type III interferon-mediated signaling pathway. Is active in plasma membrane. Implicated in asthma; hepatitis B; immunodeficiency 27A; immunodeficiency 27B; and tuberculosis. Biomarker of arteriosclerosis; periodontitis; pulmonary hypertension; and uveitis.

小鼠 Mouse Ifngr1 分子靶点信息

小鼠 Mouse Ifngr1 靶点分子功能（预测）

Predicted to enable type II interferon receptor activity. Involved in glial cell activation; negative regulation of amyloid-beta clearance; and positive regulation of macromolecule metabolic process. Acts upstream of or within defense response to virus. Predicted to be located in dendrite and vesicle. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; bone; cerebral cortex; female reproductive system; and liver. Used to study osteoporosis. Human ortholog(s) of this gene implicated in asthma; hepatitis B; immunodeficiency 27A; immunodeficiency 27B; and tuberculosis. Orthologous to human IFNGR1 (interferon gamma receptor 1).

大鼠 Rat Ifngr1 分子靶点信息

大鼠 Rat Ifngr1 靶点分子功能（预测）

Predicted to enable type II interferon receptor activity. Predicted to be involved in several processes, including glial cell activation; interferon-mediated signaling pathway; and positive regulation of macromolecule metabolic process. Predicted to act upstream of or within defense response to virus. Located in dendrite and vesicle. Human ortholog(s) of this gene implicated in asthma; hepatitis B; immunodeficiency 27A; immunodeficiency 27B; and tuberculosis. Orthologous to human IFNGR1 (interferon gamma receptor 1).

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