FGF19 靶点信息

FGF19 分子靶点信息概述

  • 分子名：FGF19, fibroblast growth factor 19
  • 基因家族：Fibroblast growth factor family

FGF19 分子靶点综述

成纤维细胞生长因子19(FGF-19)在人类中由FGF-19基因编码。FGF-19调控胆汁酸的合成，在肝脏中通过FGFR4/Klotho-β受体复合物对CYP7A1产生抑制作用。在小鼠模型中发现，FGF-19也具有代谢作用，可影响葡萄糖和脂类代谢。因胆汁酸吸收障碍的慢性腹泻患者的FGF-19减少。在胆汁郁积患者的肝脏中也存在FGF-19。代谢综合征、非酒精性脂肪肝和胰岛素耐受患者的FGF-19表达减少。而经过Roux-en-Y胃旁路减肥手术的肥胖患者，其FGF-19上升至正常水平。

FGF19, fibroblast growth factor 19 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human FGF19 分子靶点信息

人 Human FGF19靶点分子功能（预测）

Enables fibroblast growth factor receptor binding activity. Involved in several processes, including negative regulation of bile acid biosynthetic process; positive regulation of MAPK cascade; and positive regulation of glucose import. Acts upstream of or within fibroblast growth factor receptor signaling pathway and positive regulation of cell population proliferation. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and extracellular space.

小鼠 Mouse Fgf15 分子靶点信息

小鼠 Mouse Fgf15 靶点分子功能（预测）

Predicted to enable fibroblast growth factor receptor binding activity and growth factor activity. Acts upstream of or within several processes, including negative regulation of bile acid biosynthetic process; neural crest cell migration; and response to bacterium. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and extracellular space. Is expressed in several structures, including brain; branchial arch endoderm; embryo ectoderm; mesonephros; and sensory organ. Orthologous to human FGF19 (fibroblast growth factor 19).

大鼠 Rat Fgf19 分子靶点信息

  • 分子名：Fgf19, fibroblast growth factor 19
  • 别称：
    • Fgf15
    • Fgf8a
    • fibroblast growth factor 15
    • fibroblast growth factor 8a
  • 基因序列：NCBI_Gene: 170582
  • 蛋白序列：UniProtKB: Q8VI81

大鼠 Rat Fgf19 靶点分子功能（预测）

Predicted to enable fibroblast growth factor receptor binding activity and growth factor activity. Involved in bile acid and bile salt transport; response to ethanol; and response to organic cyclic compound. Predicted to be active in cytoplasm and extracellular space. Biomarker of alcoholic hepatitis. Orthologous to human FGF19 (fibroblast growth factor 19).

FGF19 分子产品列表

FGF19 分子靶点最新资讯