EGF 靶点信息

EGF 分子靶点信息概述

  • 分子名：EGF, epidermal growth factor
  • 全称：Pro-epidermal growth factor; epidermal growth factor (beta-urogastrone)

EGF 分子靶点综述

表皮生长因子(EGF)是一种通过与其受体EGFR结合，刺激细胞生长、增殖和分化的生长因子。EGF是小分子量多肽，最迟从小鼠下颌下腺纯化得到，随后在很多人的组织中均有发现，包括下颌下腺和腮腺。由饮食中的无机碘调控的唾液EGF在维持奥罗食管和胃组织健全方面具有重要的生理作用。唾液EGF的生理作用包括治愈口腔和胃溃疡、抑制胃酸分泌、刺激DNA合成以及保护粘膜免受腔内有害因素(如胃酸、胆汁酸、胃蛋白酶和胰蛋白酶)和物理、化学和细菌因素破坏。在某些通常与受体的突变和功能异常(如不依赖于EGF水平或与EGF结合的组成性受体信号传导)有关的癌症中，可观察到EGF受体活性增强。

EGF, epidermal growth factor 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human EGF 分子靶点信息

  • 分子名：EGF, epidermal growth factor
  • 别称：
    • beta-urogastrone
    • HOMG4
    • pro-epidermal growth factor
    • URG
  • 基因序列：NCBI_Gene: 1950
  • 蛋白序列：UniProtKB: P01133

人 Human EGF靶点分子功能（预测）

Enables growth factor activity and guanyl-nucleotide exchange factor activity. Involved in several processes, including ERK1 and ERK2 cascade; positive regulation of macromolecule metabolic process; and positive regulation of signal transduction. Acts upstream of or within positive regulation of cell population proliferation. Located in extracellular exosome. Implicated in several diseases, including Zollinger-Ellison syndrome; hepatobiliary system cancer (multiple); high grade glioma (multiple); lung non-small cell carcinoma (multiple); and primary hypomagnesemia (multiple). Biomarker of several diseases, including acute kidney failure; lupus nephritis; neurodegenerative disease (multiple); pancreatic cancer (multiple); and pancreatitis.

小鼠 Mouse Egf 分子靶点信息

小鼠 Mouse Egf 靶点分子功能（预测）

Enables epidermal growth factor receptor binding activity. Involved in several processes, including negative regulation of cholesterol efflux; positive regulation of ubiquitin-dependent protein catabolic process; and regulation of receptor signaling pathway via JAK-STAT. Acts upstream of or within several processes, including mammary gland alveolus development; positive regulation of cerebellar granule cell precursor proliferation; and positive regulation of protein tyrosine kinase activity. Located in extracellular space and plasma membrane. Is expressed in several structures, including 1st branchial arch; alimentary system; brain; genitourinary system; and liver and biliary system. Human ortholog(s) of this gene implicated in several diseases, including Zollinger-Ellison syndrome; hepatobiliary system cancer (multiple); high grade glioma (multiple); lung non-small cell carcinoma (multiple); and primary hypomagnesemia (multiple). Orthologous to human EGF (epidermal growth factor).

大鼠 Rat Egf 分子靶点信息

大鼠 Rat Egf 靶点分子功能（预测）

Enables epidermal growth factor receptor binding activity. Involved in several processes, including positive regulation of DNA biosynthetic process; positive regulation of ERK1 and ERK2 cascade; and positive regulation of fibroblast proliferation. Acts upstream of or within regulation of protein transport. Located in extracellular space. Used to study perinatal necrotizing enterocolitis. Biomarker of acute kidney failure. Human ortholog(s) of this gene implicated in several diseases, including Zollinger-Ellison syndrome; hepatobiliary system cancer (multiple); high grade glioma (multiple); lung non-small cell carcinoma (multiple); and primary hypomagnesemia (multiple). Orthologous to human EGF (epidermal growth factor).

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