CTLA4 靶点信息

CTLA4 分子靶点信息概述

  • 分子名：CTLA4, cytotoxic T-lymphocyte associated protein 4
  • 基因家族：CD molecules; V-set domain containing
  • 别名：CD152; CD; GSE; CTLA-4
  • 曾用名：CELIAC3; IDDM12
  • 全称：celiac disease 3; insulin-dependent diabetes mellitus 12

CTLA4 分子靶点综述

细胞毒性 T 淋巴细胞相关蛋白 4 (CTLA-4)，又名 CD152，是免疫球蛋白超家族中的成员，在辅助型 T 细胞表面表达。 CTLA-4 类似于 T 细胞的共刺激蛋白 CD28，它们都结合 CD80 和 CD86。CTLA-4 传递抑制信号给 T 细胞，而 CD28 则传 递刺激信号。CTLA-4 可作为免疫检查点发挥功能、下调免疫系统、当结合抗原递呈细胞表面的 CD80 或 CD86 时作为“关 闭”开关。细胞内的 CTLA-4 同样存在于调节性 T 细胞中，对它们的功能发挥是重要的。该基因突变与胰岛素依赖型糖尿病、甲状腺机能亢进、桥本甲状腺炎、乳糜泻、系统性红斑狼疮、甲状腺相关眼病、 原发性胆汁性肝硬化和其它自身免疫性疾病有关。CTLA-4 基因的多态性与自身免疫性疾病如自身免疫性甲状腺疾病和多 发性硬化症有关，但这种关联性通常较弱。在系统性红斑狼疮中，人们发现可溶性 CTLA-4 的剪接变异体异常产生，且存 在于患有该病的患者血清中。

CTLA4, cytotoxic T-lymphocyte associated protein 4 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human CTLA4 分子靶点信息

  • 分子名：CTLA4, cytotoxic T-lymphocyte associated protein 4
  • 别称：
    • ALPS5
    • CD
    • CD152
    • cd152 antigen
    • CD152 isoform
    • celiac disease 3
    • CELIAC3
    • CTLA-4
    • cytotoxic T lymphocyte associated antigen 4 short spliced form
    • cytotoxic T-lymphocyte antigen 4
    • cytotoxic T-lymphocyte protein 4
    • cytotoxic T-lymphocyte-associated antigen 4
    • cytotoxic T-lymphocyte-associated protein 4
    • cytotoxic T-lymphocyte-associated serine esterase-4
    • GRD4
    • GSE
    • ICOS
    • IDDM12
    • insulin-dependent diabetes mellitus 12
    • ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4
  • 基因序列：NCBI_Gene: 1493
  • 蛋白序列：UniProtKB: P16410

人 Human CTLA4靶点分子功能（预测）

Involved in several processes, including B cell receptor signaling pathway; negative regulation of lymphocyte activation; and positive regulation of apoptotic process. Located in several cellular components, including clathrin-coated endocytic vesicle; external side of plasma membrane; and perinuclear region of cytoplasm. Is integral component of plasma membrane. Part of protein complex involved in cell adhesion. Implicated in several diseases, including carcinoma (multiple); hematologic cancer (multiple); hepatitis B; kidney disease (multiple); and primary immunodeficiency disease (multiple). Biomarker of several diseases, including Sjogren's syndrome; anogenital venereal wart; hepatitis A; lung disease (multiple); and tropical spastic paraparesis.

小鼠 Mouse Ctla4 分子靶点信息

小鼠 Mouse Ctla4 靶点分子功能（预测）

Predicted to be involved in several processes, including antigen receptor-mediated signaling pathway; negative regulation of lymphocyte activation; and positive regulation of apoptotic process. Predicted to act upstream of or within adaptive immune response. Located in external side of plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); hematologic cancer (multiple); hepatitis B; kidney disease (multiple); and primary immunodeficiency disease (multiple). Orthologous to human CTLA4 (cytotoxic T-lymphocyte associated protein 4).

大鼠 Rat Ctla4 分子靶点信息

大鼠 Rat Ctla4 靶点分子功能（预测）

Predicted to enable signaling receptor activity. Involved in negative regulation of T cell proliferation and negative regulation of immune response. Predicted to be located in Golgi apparatus; clathrin-coated endocytic vesicle; and perinuclear region of cytoplasm. Predicted to be integral component of plasma membrane. Predicted to be part of protein complex involved in cell adhesion. Predicted to be active in external side of plasma membrane. Used to study myocarditis. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); hematologic cancer (multiple); hepatitis B; kidney disease (multiple); and primary immunodeficiency disease (multiple). Orthologous to human CTLA4 (cytotoxic T-lymphocyte associated protein 4).

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