文章目录[隐藏]
CIITA 分子靶点信息概述
- 分子名：CIITA, class II major histocompatibility complex transactivator
- 基因家族：NLR family
- 别名：C2TA; NLRA
- 曾用名：MHC2TA
- 全称：NLR family, acid domain containing; nucleotide-binding oligomerization domain, leucine rich repeat and acid domain containing; MHC class II transactivator; class II, major histocompatibility complex, transactivator
CIITA 分子靶点综述
MHC全称是主要组织相容性复合体，是一组决定移植组织是否相容、与免疫应答密切相关、紧密连锁的基因群，只存在于抗原呈递细胞和淋巴细胞中。MHC Class II含有两条链，即α和β链，每个链包含两个区域，α链包含α1和α2区域，β链包含β1和β2区域，α2和β2是跨膜结构域，将MHC Class II分子锚定在细胞膜。多肽结合位点存在于α1和β1形成的异二聚体之间。
CIITA, class II major histocompatibility complex transactivator 分子靶点种属信息
人 Human CIITA 分子靶点信息
- 分子名：CIITA, class II major histocompatibility complex transactivator
- 别称：
- C2TA
- CIITAIV
- class II, major histocompatibility complex, transactivator
- MHC class II transactivator
- MHC class II transactivator type I
- MHC class II transactivator type III
- MHC2TA
- NLR family, acid domain containing
- NLRA
- nucleotide-binding oligomerization domain, leucine rich repeat and acid domain containing
- 基因序列：NCBI_Gene: 4261
- 蛋白序列：UniProtKB: P33076
人 Human CIITA靶点分子功能（预测）
Enables DNA-binding transcription factor binding activity; protein C-terminus binding activity; and transcription cis-regulatory region binding activity. Involved in negative regulation of viral entry into host cell; regulation of macromolecule biosynthetic process; and response to interferon-gamma. Acts upstream of or within response to antibiotic. Located in PML body and cytosol. Implicated in Addison's disease; MHC class II deficiency; autoimmune disease (multiple); and myocardial infarction.
小鼠 Mouse Ciita 分子靶点信息
- 分子名：Ciita, class II transactivator
- 别称：
- C2ta
- EG669998
- Gm9475
- predicted gene 9475
- predicted gene, EG669998
- 基因序列：NCBI_Gene: 12265
- 蛋白序列：
小鼠 Mouse Ciita 靶点分子功能（预测）
Predicted to enable DNA-binding transcription factor binding activity; protein C-terminus binding activity; and transcription cis-regulatory region binding activity. Involved in positive regulation of transcription by RNA polymerase II and response to interferon-gamma. Acts upstream of or within negative regulation of transcription, DNA-templated. Predicted to be located in PML body; cell surface; and cytosol. Is expressed in bladder; central nervous system; and retina. Used to study MHC class II deficiency and osteoporosis. Human ortholog(s) of this gene implicated in Addison's disease; MHC class II deficiency; autoimmune disease (multiple); and myocardial infarction. Orthologous to human CIITA (class II major histocompatibility complex transactivator).
大鼠 Rat Ciita 分子靶点信息
- 分子名：Ciita, class II, major histocompatibility complex, transactivator
- 别称：
- C2ta
- class II transactivator
- MHC class II transactivator
- MHC class II transactivator type IV
- Mhc2ta
- 基因序列：NCBI_Gene: 85483
- 蛋白序列：
大鼠 Rat Ciita 靶点分子功能（预测）
Predicted to enable DNA-binding transcription factor binding activity; protein C-terminus binding activity; and transcription cis-regulatory region binding activity. Involved in several processes, including cellular response to electrical stimulus; cellular response to exogenous dsRNA; and regulation of macromolecule biosynthetic process. Located in cell surface. Used to study periapical periodontitis. Human ortholog(s) of this gene implicated in Addison's disease; MHC class II deficiency; autoimmune disease (multiple); and myocardial infarction. Orthologous to human CIITA (class II major histocompatibility complex transactivator).
