CD3E 靶点信息

CD3E 分子靶点信息概述

  • 分子名：CD3E, CD3e molecule
  • 基因家族：CD molecules
  • 全称：CD3e antigen, epsilon polypeptide (TiT3 complex); CD3e molecule, epsilon (CD3-TCR complex)

CD3E 分子靶点综述

CD3也称为T3，是免疫球蛋白超家族的一员，在抗原识别、信号传导和T细胞活化中具有重要作用。CD3ε的分子量为20 kD，是CD3分子的亚基，后者由2个CD3ε、1个CD3γ、1个CD3δ和1个CD3ζ (CD247)构成，并与α/β或γ/δT细胞受体(TCR)形成异源二聚体。CD3表达于所有成熟T细胞、NKT细胞和部分胸腺细胞。

CD3E, CD3e molecule 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human CD3E 分子靶点信息

  • 分子名：CD3E, CD3e molecule
  • 别称：
    • CD3-epsilon
    • CD3e antigen, epsilon polypeptide (TiT3 complex)
    • CD3e molecule, epsilon (CD3-TCR complex)
    • FLJ18683
    • IMD18
    • T-cell antigen receptor complex, epsilon subunit of T3
    • T-cell surface antigen T3/Leu-4 epsilon chain
    • T-cell surface glycoprotein CD3 epsilon chain
    • T3E
    • TCRE
  • 基因序列：NCBI_Gene: 916
  • 蛋白序列：UniProtKB: P07766

人 Human CD3E靶点分子功能（预测）

Enables SH3 domain binding activity; identical protein binding activity; and protein heterodimerization activity. Involved in negative regulation of gene expression; positive regulation of T cell proliferation; and positive regulation of gene expression. Located in endoplasmic reticulum and external side of plasma membrane. Part of alpha-beta T cell receptor complex. Implicated in immunodeficiency 18. Biomarker of severe acute respiratory syndrome.

小鼠 Mouse Cd3e 分子靶点信息

小鼠 Mouse Cd3e 靶点分子功能（预测）

Predicted to enable several functions, including SH3 domain binding activity; identical protein binding activity; and protein heterodimerization activity. Involved in nervous system development and positive regulation of cell adhesion. Acts upstream of or within several processes, including positive regulation of T cell activation; positive regulation of cytokine production; and regulation of signal transduction. Located in several cellular components, including dendritic spine; external side of plasma membrane; and immunological synapse. Part of alpha-beta T cell receptor complex. Is expressed in colon and hemolymphoid system. Human ortholog(s) of this gene implicated in immunodeficiency 18. Orthologous to human CD3E (CD3e molecule).

大鼠 Rat Cd3e 分子靶点信息

  • 分子名：Cd3e, CD3e molecule
  • 别称：
    • CD3 antigen, epsilon polypeptide
    • CD3 molecule, epsilon
    • CD3 molecule, epsilon polypeptide
    • LOC315609
    • T-cell surface glycoprotein CD3 epsilon chain
  • 基因序列：NCBI_Gene: 315609
  • 蛋白序列：

大鼠 Rat Cd3e 靶点分子功能（预测）

Predicted to enable several functions, including SH3 domain binding activity; identical protein binding activity; and protein heterodimerization activity. Involved in T cell differentiation in thymus; positive regulation of T cell proliferation; and response to nutrient. Predicted to be located in several cellular components, including cell body; dendritic spine; and immunological synapse. Predicted to be part of alpha-beta T cell receptor complex. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in immunodeficiency 18. Orthologous to human CD3E (CD3e molecule).

CD3E 分子产品列表

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