CD33 靶点信息

CD33 分子靶点信息概述

  • 分子名：CD33, CD33 molecule
  • 基因家族：CD molecules; V-set domain containing; Sialic acid binding Ig like lectins
  • 别名：SIGLEC3; SIGLEC-3; p67; FLJ00391
  • 全称：sialic acid binding Ig-like lectin 3; CD33 antigen (gp67)

CD33 分子靶点综述

该 P67.6 单克隆抗体与人 CD33(又称 GP67 和 P67)反应，这是一种 67kDa 的 I 型跨膜糖蛋白，是Siglec(唾液酸结合 Ig 超家族凝集素)家族的成员。CD33 表达于髓系前体细胞、粒细胞和单核细胞，正常人 CD33 的表达强度有变异。各 AML 亚型均有 CD33 的表达，10% ~ 20%的 ALL 也可伴 CD33 表达。

CD33, CD33 molecule 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human CD33 分子靶点信息

  • 分子名：CD33, CD33 molecule
  • 别称：
    • CD33 antigen (gp67)
    • CD33 molecule transcript
    • FLJ00391
    • gp67
    • myeloid cell surface antigen CD33
    • p67
    • sialic acid binding Ig-like lectin 3
    • sialic acid-binding Ig-like lectin 3
    • SIGLEC-3
    • SIGLEC3
  • 基因序列：NCBI_Gene: 945
  • 蛋白序列：UniProtKB: P20138

人 Human CD33靶点分子功能（预测）

Enables protein phosphatase binding activity and sialic acid binding activity. Involved in several processes, including negative regulation of cytokine production; negative regulation of monocyte activation; and positive regulation of protein tyrosine phosphatase activity. Located in several cellular components, including Golgi apparatus; external side of plasma membrane; and peroxisome.

小鼠 Mouse Cd33 分子靶点信息

小鼠 Mouse Cd33 靶点分子功能（预测）

Predicted to enable protein phosphatase binding activity and sialic acid binding activity. Predicted to be involved in several processes, including negative regulation of cytokine production; negative regulation of monocyte activation; and positive regulation of protein tyrosine phosphatase activity. Predicted to be located in several cellular components, including Golgi apparatus; external side of plasma membrane; and peroxisome. Predicted to be active in plasma membrane. Is expressed in central nervous system; genitourinary system; spleen; and submandibular gland. Orthologous to human CD33 (CD33 molecule).

大鼠 Rat Cd33 分子靶点信息

  • 分子名：Cd33, CD33 molecule
  • 别称：
    • LOC690492
    • myeloid cell surface antigen CD33
    • similar to CD33 antigen
  • 基因序列：NCBI_Gene: 690492
  • 蛋白序列：UniProtKB: F1LTZ3

大鼠 Rat Cd33 靶点分子功能（预测）

Predicted to enable protein phosphatase binding activity and sialic acid binding activity. Predicted to be involved in several processes, including negative regulation of cytokine production; negative regulation of monocyte activation; and positive regulation of protein tyrosine phosphatase activity. Predicted to be located in several cellular components, including Golgi apparatus; external side of plasma membrane; and peroxisome. Predicted to be active in plasma membrane. Orthologous to human CD33 (CD33 molecule).

CD33 分子产品列表

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