ANGPTL4 靶点信息

ANGPTL4 分子靶点信息概述

  • 分子名：ANGPTL4, angiopoietin like 4
  • 基因家族：Fibrinogen C domain containing; Angiopoietin like family
  • 别名：pp1158; PGAR; ARP4; HFARP; FIAF; NL2
  • 全称：fasting-induced adipose factor; hepatic angiopoietin-related protein; PPARG angiopoietin related protein; hepatic fibrinogen/angiopoietin-related protein; peroxisome proliferator-activated receptor (PPAR) gamma induced angiopoietin-related protein; angiopoietin-related protein 4; angiopoietin-like 4

ANGPTL4 分子靶点综述

血管生成素样蛋白，也被称为血管生成素相关蛋白，在结构上与血管生成素相关。在人类中，血管生成素样蛋白4是由ANGPTL4基因编码的一种蛋白质。该基因以前也被称为ANGPTL2、HFARP、PGAR或FIAF，但已被重新命名为ANGPTL4。ANGPTL4是血管生成素样基因家族的成员，编码分泌型的糖基化蛋白。ANGPTL4在脂肪组织中高度表达。缺氧时，在内皮细胞和心肌细胞中表达上调。ANGPTL4参与调节脂肪和葡萄糖代谢，它也与血管的生成有关。ANGPTL4在缺氧的人体组织以及脂肪肉瘤、肝细胞癌和常规肾细胞癌等各种癌症中也有表达。

ANGPTL4, angiopoietin like 4 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human ANGPTL4 分子靶点信息

  • 分子名：ANGPTL4, angiopoietin like 4
  • 别称：
    • angiopoietin-like 4
    • angiopoietin-like protein 4
    • angiopoietin-related protein 4
    • ANGPTL2
    • ARP4
    • fasting-induced adipose factor
    • FIAF
    • HARP
    • hepatic angiopoietin-related protein
    • hepatic fibrinogen/angiopoietin-related protein
    • HFARP
    • NL2
    • peroxisome proliferator-activated receptor (PPAR) gamma induced angiopoietin-related protein
    • PGAR
    • pp1158
    • PPARG angiopoietin related protein
    • TGQTL
    • UNQ171
  • 基因序列：NCBI_Gene: 51129
  • 蛋白序列：UniProtKB: Q9BY76

人 Human ANGPTL4靶点分子功能（预测）

Enables identical protein binding activity. Involved in negative regulation of apoptotic process; negative regulation of lipoprotein lipase activity; and protein unfolding. Located in extracellular space.

小鼠 Mouse Angptl4 分子靶点信息

小鼠 Mouse Angptl4 靶点分子功能（预测）

Enables enzyme inhibitor activity. Involved in negative regulation of apoptotic process; negative regulation of lipoprotein lipase activity; and triglyceride homeostasis. Acts upstream of or within negative regulation of endothelial cell apoptotic process. Located in extracellular space. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system gland; integumental system; and musculature. Orthologous to human ANGPTL4 (angiopoietin like 4).

大鼠 Rat Angptl4 分子靶点信息

  • 分子名：Angptl4, angiopoietin-like 4
  • 别称：
    • angiopoietin-like protein 4
    • angiopoietin-related protein 4
    • hepatic fibrinogen/angiopoietin-related protein
    • HFARP
    • LOC362850
  • 基因序列：NCBI_Gene: 362850
  • 蛋白序列：UniProtKB: Q6TMA8

大鼠 Rat Angptl4 靶点分子功能（预测）

Enables identical protein binding activity. Involved in response to hypoxia. Predicted to be located in extracellular region. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Orthologous to human ANGPTL4 (angiopoietin like 4).

ANGPTL4 分子产品列表

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