作者：联科生物 发布日期：2017-11-07 09:00
获奖文章题目：Cuprous oxide nanoparticles inhibit the growth of cervical carcinoma by inducing autophagy.
摘要：Cervical carcinoma is one of the main causes of women’s cancer, and substantial side effects from standard treatment including platinum-based chemotherapy limit the options for escalation. In this paper, using cervical cancer cell lines and tumor-bearing mice as models, we report that CONPs could inhibit the proliferation of cancer cells in vitro and in vivo. Especially CONPs could inhibit tumor growth as cisplatin without weight loss. CONPs could also induce autophagy through AKT/mTOR pathway, which demonstrates that CONPs has the potential clinical applications.
联科试剂：Apoptosis assay was performed using an AnnexinV-FITC/PI Apoptosis Detection Kit (Multi Sciences (Lianke) Biotech Co.,Ltd., Hangzhou, China) by flow cytometry according to the protocol provided.Cell cycle assay was assessed by flow cytometry using a cell cycle staining Kit (Multi Sciences (Lianke) Biotech Co., Ltd., Hangzhou,China) according to the protocol provided.