Schisandrin B-mediated TH17 cell differentiation attenuates bowel inflammation

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  • 作者：Zeyu Ma, Gang Xu, Yingying Shen, Shufang Hu, Xia Lin, Jun Zhou, Wei Zhao, Jian Liu, Jiaoli Wang, Jufeng Guo
  • 期刊：PHARMACOLOGICAL RESEARCH
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Schisandrin B (Sch B) is the major active constituent of the traditional Chinese medicine Schisandra chinensis and has anti-inflammatory activity, but the target of Sch B remains unclear. T helper 17 (TH17) cells have been involved in the pathogenesis of many autoimmune and inflammatory diseases. Here, we showed that Sch B could decrease IL-17A production of CD4+ T cells by targeting STAT3 in vitro. Importantly, Sch B has therapeutic effects on DSS-induced acute and chronic colitis, CD4+CD45RBhigh T cell-induced colitis. Furthermore, we identified TH17 cells as the direct target of Sch B for mediating its anti-inflammatory activity. Sch B could serve as a lead for developing new therapeutics against TH17 cells or IL-17A cytokine-driven diseases.

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