Correlation of apolipoprotein A-I with T cell subsets and interferon-? in coronary artery disease

Background The association of Apolipoprotein A-I (APOAI) with T cell subsets and interferon-? (IFN-γ) in patients with coronary artery disease (CAD) has been not reported. Thus, this study aimed to investigate the association of APOAI with T cell subsets and IFN-γ in CAD. Methods This study included a total of 107 patients with CAD including acute coronary syndrome and chronic coronary syndrome. T cell subsets, and CD3-CD56+ natural killer cells were quantified by flow cytometric analysis. The serum concentrations of IFN-? were measured by enzyme-linked immunosorbent assay. Lipid profiles, C-reactive protein (CRP), and fibrinogen were measured in the clinical laboratory. Clinical data was obtained duration hospitalization. Results The CD4+ T cells were higher in patients of the low-APOAI group (<median: 1.2?mmol/L) than in patients of the high-APOAI group(≥median: 1.2?mmol/L) ( p <?.05). The CD8+ T cells were lower in patients of the low APOAI group than in patients of the high-APOAI group ( p <?.05). APOAI was inversely associated with CD4+?T cells, IFN-γ, and was positively associated with CD8+?T cells ( p ?.05). The high-density lipoprotein cholesterol (HDL-C) was also inversely associated with CD4+ T cells ( p <?.05), and positively associated with CD8+ T cells ( p ?.05). Conclusion The present study demonstrated the correlation of APOAI with T cell subsets and IFN-γ in CAD. These results provided novel information for the regulatory action between APOAI and T cell subsets and inflammatory immunity in CAD.

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