基本信号传导系统:Notch信号通路

  • Post category:生物资讯
  • Post views:3948 次访问

https://www.liankebio.com/article-information_Newsletter-1311.html

作者:ROCKLAND官网 发布日期:2013-09-03 12:00

Notch通路是最基本的信号传导系统,使相邻的细胞相互调节、发挥其合适的发育作用。Notch蛋白通过细胞与细胞接触来介导重要的细胞功能。Notch信号传导包括调节胚胎和成年期多种细胞分化进程的基因调控机制。Notch受体是单次跨膜蛋白,包括功能性胞外区(NECD)、跨膜区(TM)和胞内区。在接收信号的细胞中,γ-分泌酶(也参与阿尔茨海默病) 可以在Notch 跨膜区的S3 位点水解,产生Notch 细胞内结构域(notch intracellular domain, NICD)。NICD转移入核与CSL (CBF1/Su(H)/Lag-1)形成复合物,从而激活Myc、p21和HES家族。

产品名称 货号 规格 应用 目录价(¥)
Anti-NOTCH 1 (intra) (RABBIT) Antibody RK-100-401-405 200μl E, IHC, WB 4704.00
Anti-NOTCH 2 (intra) (Human specific) (RABBIT) Antibody RK-100-401-406 200μl E, IHC, WB 4704.00
Anti-NOTCH 1 (Cleaved N terminal) (Human specific) (RABBIT) Antibody RK-100-401-407 200μl E, WB 4704.00
Anti-NOTCH 2 (Cleaved N terminal) (Human specific) (RABBIT) Antibody RK-100-401-408 200μl E, IHC, WB 4704.00
Anti-DELTA-4 (RABBIT) Antibody RK-600-401-696 100μg E, IHC, WB 4704.00
Anti-Jagged-2 (RABBIT) Antibody RK-600-401-852 100μg E, WB 4704.00
Anti-Jagged-1 (RABBIT) Antibody RK-200-401-698 500μg E, IF, IHC, WB 4704.00
Anti-ADAM10 (RABBIT) Antibody RK-200-401-949 100μg E, IF, IHC, WB 4704.00
Anti-Mouse DELTA-1 (RABBIT) Antibody RK-600-401-858 100μg E, WB 4704.00
Anti-NOTCH 1 (Cleaved N terminal)(Human specific) (RABBIT) Antibody (Cat No. 100-401-407)染色人胰腺的免疫组化图片。 Anti-Jagged-1 (RABBIT) Antibody (Cat No. 200-401-698)染色人角膜上皮细胞的免疫荧光图片。 Anti-DELTA-4 (RABBIT) Antibody (Cat No. 600-401-696)在小鼠胰腺组织 中检测到74kDa的特异性条带。