INS 分子靶点信息概述

  • 分子名:INS, insulin
  • 基因家族:Neuropeptides
  • 曾用名:IDDM2; IDDM1
  • 全称:insulin-dependent diabetes mellitus 2

INS 分子靶点综述

胰岛素是一种由胰岛β细胞和一些硬骨鱼布氏体分泌产生的肽类激素。它通过促进脂肪、肝脏和骨骼肌细胞吸收血液中的葡萄糖,从而对糖类、脂肪和蛋白质代谢起重要作用。这些组织吸收的葡萄糖转化为糖原或者脂肪(甘油三酯), 而肝脏是个例外,其吸收的葡萄糖可以转化为糖原和脂肪。肝脏中的葡萄糖产量受血液中高浓度胰岛素强烈抑制。血液中胰岛素浓度高时,它就是一种同化激素,可促进血液中的小分子转化为细胞内的大分子。血液中胰岛素浓度低时,它通过促进广泛的分解代谢而产生相反的效果。当胰岛β细胞被自身免疫过程破坏,胰岛素就不再合成或者分泌到血液中,进而导致 1 型糖尿病。遗传易感性和环境因素的综合影响会导致胰岛素抵抗,这就是 2 型糖尿病。另外,胰岛β细胞产生过量的胰岛素或反应性低血糖都与胰岛素瘤有关。

INS, insulin 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human INS 分子靶点信息

  • 分子名:INS, insulin
  • 别称:
    • IDDM
    • IDDM1
    • IDDM2
    • ILPR
    • insulin-dependent diabetes mellitus 2
    • IRDN
    • MODY10
    • PNDM4
    • preproinsulin
    • proinsulin
  • 基因序列:NCBI_Gene: 3630
  • 蛋白序列:UniProtKB: P01308

人 Human INS靶点分子功能(预测)

Enables identical protein binding activity; protease binding activity; and signaling receptor binding activity. Involved in several processes, including positive regulation of signal transduction; regulation of generation of precursor metabolites and energy; and regulation of protein metabolic process. Located in extracellular space. Implicated in diabetic retinopathy; glucose metabolism disease (multiple); insulinoma; and pancreatic cancer. Biomarker of disease of metabolism (multiple); osteoarthritis; pancreatic ductal carcinoma; and prostate cancer.

小鼠 Mouse Ins2 分子靶点信息

小鼠 Mouse Ins2 靶点分子功能(预测)

Predicted to enable identical protein binding activity; protease binding activity; and signaling receptor binding activity. Acts upstream of or within several processes, including cell surface receptor signaling pathway; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; and positive regulation of phosphorylation. Located in cytosol; nucleus; and secretory granule. Part of sno(s)RNA-containing ribonucleoprotein complex. Is expressed in several structures, including brain; extraembryonic component; gut; immune system; and testis. Used to study maturity-onset diabetes of the young; neonatal diabetes; permanent neonatal diabetes mellitus; type 1 diabetes mellitus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in diabetic retinopathy; glucose metabolism disease (multiple); insulinoma; and pancreatic cancer. Orthologous to several human genes including INS (insulin).

大鼠 Rat Ins2 分子靶点信息

  • 分子名:Ins2, insulin 2
  • 别称:
    • C-peptide
    • CP-II
    • insulin-2
    • LOC102549619
    • uncharacterized LOC102549619
  • 基因序列:NCBI_Gene: 24506
  • 蛋白序列:UniProtKB: P01323

大鼠 Rat Ins2 靶点分子功能(预测)

Predicted to enable several functions, including identical protein binding activity; signaling receptor binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including negative regulation of catabolic process; positive regulation of macromolecule metabolic process; and positive regulation of signal transduction. Predicted to act upstream of or within several processes, including cell surface receptor signaling pathway; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; and positive regulation of phosphorylation. Located in extracellular space. Colocalizes with secretory granule. Used to study hypertension. Biomarker of Alzheimer's disease. Human ortholog(s) of this gene implicated in diabetic retinopathy; glucose metabolism disease (multiple); insulinoma; and pancreatic cancer. Orthologous to human INS (insulin).

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