ACE 靶点信息

ACE 分子靶点信息概述

  • 分子名：ACE, angiotensin I converting enzyme
  • 基因家族：CD molecules
  • 别名：ACE1; CD143
  • 曾用名：DCP1
  • 全称：peptidyl-dipeptidase A; angiotensin I converting enzyme (peptidyl-dipeptidase A) 1

ACE 分子靶点综述

血管紧张素Ⅰ转换酶(ACE)，又称二肽基肽酶A，是一种锌金属肽酶，对血压控制和水盐代谢具有重要意义。ACE通过释放末端His-Leu二肽将血管紧张素I转化为血管紧张素II，从而增加血管紧张素的缩血管活性。它也能使缓激肽失活，后者是一种有效的血管扩张剂。ACE和ACE-2是两种细胞表面蛋白酶，是肾素-血管紧张素系统(RAS)的重要调节因子，在维持哺乳动物血压稳态和水盐平衡中起着关键作用。ACE以2种形态存在于人体中，一种表达于体细胞，称为sACE(somatic ACE)，另一种表达于生殖细胞，称为gACE(germinal ACE)。2种形态的ACE主要不同点在于gACE只含有一个C端活性功能区，而sACE含有C端和N端2个活性功能区。因此，2种ACE的催化活性不同，在最重要的RAS升压调节系统中，sACE有更加关键的作用。ACE-2由一个蛋白酶结构域组成，是心肺功能的重要调节因子。它也是引起严重急性呼吸综合征的SARS病毒以及新冠病毒刺突蛋白的细胞受体。

ACE, angiotensin I converting enzyme 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human ACE 分子靶点信息

  • 分子名：ACE, angiotensin I converting enzyme
  • 别称：
    • ACE1
    • angiotensin 1 converting enzyme 1
    • angiotensin converting enzyme, somatic isoform
    • angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
    • angiotensin I converting enzyme peptidyl-dipeptidase A 1 transcript
    • angiotensin-converting enzyme
    • carboxycathepsin
    • CD143
    • CD143 antigen
    • DCP
    • DCP1
    • dipeptidyl carboxypeptidase 1
    • dipeptidyl carboxypeptidase I
    • ICH
    • kininase II
    • MGC26566
    • MVCD3
    • peptidase P
    • testicular ECA
  • 基因序列：NCBI_Gene: 1636
  • 蛋白序列：UniProtKB: P12821

人 Human ACE靶点分子功能（预测）

Enables several functions, including chloride ion binding activity; peptidase activity; and protein kinase binding activity. Involved in several processes, including arachidonic acid secretion; peptide metabolic process; and regulation of angiotensin metabolic process. Located in several cellular components, including external side of plasma membrane; extracellular exosome; and lysosome. Implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); gastrointestinal system cancer (multiple); heart valve disease (multiple); and lung disease (multiple). Biomarker of several diseases, including chronic myeloid leukemia; intermediate coronary syndrome; lung disease (multiple); pancreatic ductal carcinoma; and renal fibrosis.

小鼠 Mouse Ace 分子靶点信息

小鼠 Mouse Ace 靶点分子功能（预测）

Enables metallopeptidase activity and peptidyl-dipeptidase activity. Involved in several processes, including cell proliferation in bone marrow; positive regulation of protein modification process; and regulation of gene expression. Acts upstream of or within several processes, including heart contraction; neutrophil mediated immunity; and positive regulation of systemic arterial blood pressure. Located in cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and integumental system. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); gastrointestinal system cancer (multiple); heart valve disease (multiple); and lung disease (multiple). Orthologous to human ACE (angiotensin I converting enzyme).

大鼠 Rat Ace 分子靶点信息

  • 分子名：Ace, angiotensin I converting enzyme
  • 别称：
    • angiotensin 1 converting enzyme
    • angiotensin 1 converting enzyme 1
    • angiotensin converting enzyme
    • angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
    • angiotensin I converting enzyme 1
    • angiotensin I-converting enzyme (Dipeptidyl carboxypeptidase 1)
    • angiotensin-converting enzyme
    • angiotensin-converting enzyme-like
    • CD143
    • Dcp1
    • Dipeptidyl carboxypeptidase 1
    • Dipeptidyl carboxypeptidase 1 (Angiotensin I-converting enzyme)
    • dipeptidyl carboxypeptidase I
    • kininase II
    • LOC102556346
    • StsRR92
  • 基因序列：NCBI_Gene: 24310
  • 蛋白序列：

大鼠 Rat Ace 靶点分子功能（预测）

Enables heterocyclic compound binding activity; metallopeptidase activity; and peptidyl-dipeptidase activity. Involved in several processes, including animal organ development; negative regulation of transport; and response to corticosteroid. Located in several cellular components, including basal plasma membrane; brush border membrane; and sperm midpiece. Used to study several diseases, including artery disease (multiple); glomerulonephritis (multiple); kidney failure (multiple); lung disease (multiple); and proteinuria (multiple). Biomarker of several diseases, including artery disease (multiple); congenital diaphragmatic hernia; endomyocardial fibrosis; liver cirrhosis (multiple); and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); gastrointestinal system cancer (multiple); heart valve disease (multiple); and lung disease (multiple). Orthologous to human ACE (angiotensin I converting enzyme).

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