CSF3 靶点信息

CSF3 分子靶点信息概述

  • 分子名：CSF3, colony stimulating factor 3
  • 基因家族：Receptor ligands
  • 别名：MGC45931
  • 曾用名：GCSF; G-CSF; C17orf33
  • 全称：granulocyte colony stimulating factor; pluripoietin; filgrastim; lenograstim; chromosome 17 open reading frame 33; colony stimulating factor 3 (granulocyte)

CSF3 分子靶点综述

粒细胞集落刺激因子(G-CSF)是一种糖蛋白，可刺激骨髓产生粒细胞和干细胞，并把它们释放到血液中。从功能上来说，它是一种细胞因子和激素，是一种集落刺激因子，由内皮细胞、巨噬细胞和许多其它免疫细胞产生。G-CSF刺激中性粒细胞前体和成熟中性粒细胞的生存、增殖、分化及功能发挥。在肿瘤学和血液学上，重组G-CSF用于加速癌症患者化疗后引起的嗜中性白血球减少症的恢复。在白细胞去除前，G-CSF也可用来增加献血者血液中的造血干细胞数量，用于造血干细胞移植。

CSF3, colony stimulating factor 3 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human CSF3 分子靶点信息

  • 分子名：CSF3, colony stimulating factor 3
  • 别称：
    • C17orf33
    • chromosome 17 open reading frame 33
    • colony stimulating factor 3 (granulocyte)
    • CSF3OS
    • filgrastim
    • G-CSF
    • GCSF
    • granulocyte colony-stimulating factor
    • granulocyte-colony stimulating factor
    • lenograstim
    • MGC45931
    • pluripoietin
  • 基因序列：NCBI_Gene: 1440
  • 蛋白序列：UniProtKB: P09919

人 Human CSF3靶点分子功能（预测）

Enables cytokine activity and enzyme binding activity. Involved in several processes, including positive regulation of cytoskeleton organization; positive regulation of intracellular signal transduction; and positive regulation of protein phosphorylation. Predicted to be located in endocytic vesicle lumen; extracellular region; and lysosomal lumen. Predicted to be active in extracellular space. Implicated in several diseases, including allergic cutaneous vasculitis; artery disease (multiple); ischemia (multiple); leukemia (multiple); and lung disease (multiple). Biomarker of COVID-19; bacterial pneumonia; and myeloid leukemia.

小鼠 Mouse Csf3 分子靶点信息

小鼠 Mouse Csf3 靶点分子功能（预测）

Enables granulocyte colony-stimulating factor receptor binding activity. Acts upstream of or within positive regulation of myeloid cell differentiation. Predicted to be located in endocytic vesicle lumen and extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including brain; dorsal aorta; liver; reproductive system; and yolk sac. Human ortholog(s) of this gene implicated in several diseases, including allergic cutaneous vasculitis; artery disease (multiple); ischemia (multiple); leukemia (multiple); and lung disease (multiple). Orthologous to human CSF3 (colony stimulating factor 3).

大鼠 Rat Csf3 分子靶点信息

  • 分子名：Csf3, colony stimulating factor 3
  • 别称：
    • colony stimulating factor 3 (granulocyte)
    • Gcsf
    • granulocyte colony-stimulating factor
  • 基因序列：NCBI_Gene: 25610
  • 蛋白序列：UniProtKB: P97712

大鼠 Rat Csf3 靶点分子功能（预测）

Enables growth factor activity. Involved in several processes, including cellular response to lipopolysaccharide; negative regulation of neuron death; and response to ethanol. Located in extracellular space. Biomarker of cystitis; lung disease; and middle cerebral artery infarction. Human ortholog(s) of this gene implicated in several diseases, including allergic cutaneous vasculitis; artery disease (multiple); ischemia (multiple); leukemia (multiple); and lung disease (multiple). Orthologous to human CSF3 (colony stimulating factor 3).

CSF3 分子产品列表

CSF3 分子靶点最新资讯