IL33 靶点信息

IL33 分子靶点信息概述

  • 分子名：IL33, interleukin 33
  • 基因家族：Interleukins
  • 别名：DVS27; DKFZp586H0523; NF-HEV; IL1F11
  • 曾用名：C9orf26
  • 全称：DVS27-related protein; nuclear factor for high endothelial venules; interleukin-1 family, member 11; chromosome 9 open reading frame 26 (NF-HEV)

IL33 分子靶点综述

白细胞介素33(IL-33)也称为NF-HEV和DVS27，是IL-1家族成员，分子量为30kDa，由多种类型的细胞分泌，包括成纤维细胞、肥大细胞、树突细胞、巨噬细胞、成骨细胞、内皮细胞和上皮细胞。IL-33可诱导辅助性T细胞、肥大细胞、嗜酸性粒细胞和嗜碱性粒细胞分泌II型细胞因子。IL-33通过与受体ST2和IL-1受体辅助蛋白(IL1RAP)结合，活化可促使极化的Th2细胞分泌II型细胞因子(如IL-5和IL-13)的NF-κB和MAP激酶信号通路中的胞外分子来介导其生物学功能。注射IL-33后，其可在体内诱导II型细胞因子，这被认为可诱导粘膜器官发生严重的病理变化。

IL33, interleukin 33 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human IL33 分子靶点信息

  • 分子名：IL33, interleukin 33
  • 别称：
    • C9orf26
    • DKFZp586H0523
    • DVS27
    • DVS27-related protein
    • IL-1F11
    • IL-33
    • IL1F11
    • interleukin-1 family member 11
    • interleukin-33
    • NF-HEV
    • NFEHEV
    • nuclear factor for high endothelial venules
    • nuclear factor from high endothelial venules
    • RP11-575C20.2
  • 基因序列：NCBI_Gene: 90865
  • 蛋白序列：UniProtKB: O95760

人 Human IL33靶点分子功能（预测）

Enables cytokine activity. Involved in negative regulation of transcription by RNA polymerase II; positive regulation of chemokine production; and positive regulation of macrophage activation. Located in nucleoplasm. Part of cytoplasm and nucleus. Implicated in candidiasis; inflammatory bowel disease; and peptic ulcer disease. Biomarker of several diseases, including colitis (multiple); common cold; gout; liver disease (multiple); and tuberculosis (multiple).

小鼠 Mouse Il33 分子靶点信息

小鼠 Mouse Il33 靶点分子功能（预测）

Enables cytokine activity and interleukin-33 receptor binding activity. Involved in several processes, including interleukin-33-mediated signaling pathway; microglial cell activation involved in immune response; and regulation of gene expression. Acts upstream of or within several processes, including negative regulation of macrophage proliferation; positive regulation of cellular defense response; and positive regulation of macromolecule metabolic process. Located in nucleus. Is expressed in several structures, including adrenal gland; alimentary system; genitourinary system; nervous system; and sensory organ. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in candidiasis; inflammatory bowel disease; and peptic ulcer disease. Orthologous to human IL33 (interleukin 33).

大鼠 Rat Il33 分子靶点信息

大鼠 Rat Il33 靶点分子功能（预测）

Predicted to enable cytokine activity and interleukin-33 receptor binding activity. Involved in several processes, including cellular response to mechanical stimulus; positive regulation of oligodendrocyte differentiation; and regulation of sensory perception of pain. Located in nucleus. Biomarker of acute myocardial infarction; colon cancer; and diabetes mellitus. Human ortholog(s) of this gene implicated in candidiasis; inflammatory bowel disease; and peptic ulcer disease. Orthologous to human IL33 (interleukin 33).

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