TF 靶点信息

TF 分子靶点信息概述

  • 分子名：TF, transferrin
  • 基因家族：Transferrins
  • 别名：PRO1557; PRO2086
  • 全称：serotransferrin

TF 分子靶点综述

转铁蛋白(TF)是一种分泌蛋白，属于转铁蛋白家族，是由肝脏表达并分泌到血浆中。TF分子量约为80kDa，包含两个特异的高亲和力Fe3+结合位点。TFs是存在于血浆中的铁结合糖蛋白，可调控生物体液中的游离铁水平，它的主要作用是从十二指肠吸收中心和白细胞巨噬细胞转运铁到其它组织。TF与先天免疫系统有关。在炎症状态下，它的水平会降低。我们常见到缺铁性贫血患者中的血浆TF水平是增加的。而铁超负荷和蛋白质营养不良患者中的血浆TF水平通常是降低的。最近，人们发现当TF受体吸引抗体时，TF及其受体可减少肿瘤细胞。TF是一种急性期蛋白，因此在炎症、癌症和某些疾病中它的水平是下降的。

TF, transferrin 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human TF 分子靶点信息

  • 分子名：TF, transferrin
  • 别称：
    • beta-1 metal-binding globulin
    • DKFZp781D0156
    • epididymis secretory sperm binding protein Li 71p
    • HEL-S-71p
    • PRO1557
    • PRO2086
    • serotransferrin
    • siderophilin
    • TFQTL1
  • 基因序列：NCBI_Gene: 7018
  • 蛋白序列：UniProtKB: P02787

人 Human TF靶点分子功能（预测）

Enables ferrous iron binding activity; iron chaperone activity; and transferrin receptor binding activity. Involved in cellular response to iron ion; positive regulation of receptor-mediated endocytosis; and regulation of iron ion transport. Located in several cellular components, including basal plasma membrane; clathrin-coated pit; and cytoplasmic vesicle. Is extrinsic component of external side of plasma membrane. Part of HFE-transferrin receptor complex. Implicated in anemia; atransferrinemia; glucose metabolism disease (multiple); iron deficiency anemia; and restless legs syndrome. Biomarker of glomerulonephritis; hypertension; and membranous glomerulonephritis.

小鼠 Mouse Trf 分子靶点信息

小鼠 Mouse Trf 靶点分子功能（预测）

Predicted to enable iron chaperone activity; iron ion binding activity; and transferrin receptor binding activity. Involved in several processes, including ERK1 and ERK2 cascade; osteoclast differentiation; and positive regulation of bone resorption. Acts upstream of or within SMAD protein signal transduction; iron ion transport; and response to bacterium. Located in clathrin-coated pit and cytoplasmic vesicle. Is expressed in several structures, including brain; liver; placenta; white fat; and yolk sac. Used to study atransferrinemia. Human ortholog(s) of this gene implicated in anemia; atransferrinemia; glucose metabolism disease (multiple); iron deficiency anemia; and restless legs syndrome. Orthologous to human TF (transferrin).

大鼠 Rat Tf 分子靶点信息

大鼠 Rat Tf 靶点分子功能（预测）

Enables ferric iron binding activity. Involved in several processes, including cellular response to cAMP; cellular response to follicle-stimulating hormone stimulus; and regulation of nervous system development. Located in basement membrane; cell tip; and extracellular space. Used to study hepatitis. Biomarker of anemia and obesity. Human ortholog(s) of this gene implicated in anemia; atransferrinemia; glucose metabolism disease (multiple); iron deficiency anemia; and restless legs syndrome. Orthologous to human TF (transferrin).

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