CCL5 靶点信息

CCL5 分子靶点信息概述

  • 分子名：CCL5, C-C motif chemokine ligand 5
  • 基因家族：Chemokine ligands
  • 别名：RANTES; SISd; TCP228; MGC17164
  • 曾用名：D17S136E; SCYA5
  • 全称：T-cell specific protein p288; T-cell specific RANTES protein; SIS-delta; regulated upon activation, normally T-expressed, and presumably secreted; beta-chemokine RANTES; small inducible cytokine subfamily A (Cys-Cys), member 5; small inducible cytokine A5 (RANTES); chemokine (C-C motif) ligand 5

CCL5 分子靶点综述

趋化因子配体5(CCL5)，又名RANTES，是一种趋化细胞因子。它可趋化T细胞、嗜酸性粒细胞和嗜碱性粒细胞，在招募白细胞到炎症位点发挥着积极的作用。在T细胞释放的细胞因子如IL-2和IFN-γ的帮助下，CCL5可诱导某些自然杀伤细胞(NK)增殖和活化形成CC趋化因子活化的杀伤(CHAK)细胞。CCL5也是一种由CD8+T细胞释放的HIV抑制因子。最近，研究者正在开发完善乳酸菌体内产生CCL5的方案，以期其成为抑制HIV进入的局部杀菌剂。

CCL5, C-C motif chemokine ligand 5 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human CCL5 分子靶点信息

  • 分子名：CCL5, C-C motif chemokine ligand 5
  • 别称：
    • beta-chemokine RANTES
    • C-C motif chemokine 5
    • chemokine (C-C motif) ligand 5
    • D17S136E
    • eoCP
    • eosinophil chemotactic cytokine
    • MGC17164
    • RANTES
    • regulated upon activation, normally T-expressed, and presumably secreted
    • SCYA5
    • SIS-delta
    • SISd
    • small inducible cytokine A5 (RANTES)
    • small inducible cytokine subfamily A (Cys-Cys), member 5
    • small-inducible cytokine A5
    • t cell-specific protein P228
    • T-cell specific protein p288
    • T-cell-specific protein RANTES
    • TCP228
  • 基因序列：NCBI_Gene: 6352
  • 蛋白序列：UniProtKB: P13501

人 Human CCL5靶点分子功能（预测）

Enables several functions, including enzyme activator activity; phosphatidylinositol phospholipase C activity; and signaling receptor binding activity. Involved in several processes, including cellular response to cytokine stimulus; positive regulation of cell migration; and positive regulation of cell-cell adhesion. Acts upstream of or within positive regulation of T cell migration. Predicted to be located in cytoplasm. Predicted to be active in extracellular space. Implicated in several diseases, including hepatitis B; hepatitis C; liver disease (multiple); pulmonary tuberculosis; and severe acute respiratory syndrome. Biomarker of several diseases, including fatty liver disease (multiple); glucose metabolism disease (multiple); hypertension (multiple); liver cirrhosis (multiple); and lung disease (multiple).

小鼠 Mouse Ccl5 分子靶点信息

小鼠 Mouse Ccl5 靶点分子功能（预测）

Enables CCR1 chemokine receptor binding activity. Involved in negative regulation of macrophage apoptotic process and positive regulation of monocyte chemotaxis. Acts upstream of or within inflammatory response; positive regulation of epithelial cell proliferation; and response to tumor necrosis factor. Located in cytoplasm and extracellular space. Is expressed in several structures, including central nervous system; gonad; hemolymphoid system; late tubule; and retina. Human ortholog(s) of this gene implicated in several diseases, including hepatitis B; hepatitis C; liver disease (multiple); pulmonary tuberculosis; and severe acute respiratory syndrome. Orthologous to human CCL5 (C-C motif chemokine ligand 5).

大鼠 Rat Ccl5 分子靶点信息

  • 分子名：Ccl5, C-C motif chemokine ligand 5
  • 别称：
    • C-C motif chemokine 5
    • chemokine (C-C motif) ligand 5
    • RANTES
    • regulated upon activation normal T-cell expressed and secreted
    • Scya5
    • SIS-delta
    • small inducible cytokine A5
    • small inducible cytokine A5 (RANTES)
    • small-inducible cytokine A5
    • T-cell-specific protein RANTES
  • 基因序列：NCBI_Gene: 81780
  • 蛋白序列：

大鼠 Rat Ccl5 靶点分子功能（预测）

Enables chemokine activity and heparin binding activity. Involved in several processes, including cellular response to organonitrogen compound; lymphocyte migration; and positive regulation of leukocyte chemotaxis. Located in extracellular space. Used to study Chagas disease; bronchiolitis obliterans; kidney disease; non-alcoholic fatty liver disease; and orchitis. Biomarker of several diseases, including alcoholic hepatitis; artery disease (multiple); cardiac arrest; lung disease (multiple); and uveitis (multiple). Human ortholog(s) of this gene implicated in several diseases, including hepatitis B; hepatitis C; liver disease (multiple); pulmonary tuberculosis; and severe acute respiratory syndrome. Orthologous to human CCL5 (C-C motif chemokine ligand 5).

CCL5 分子产品列表

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