CCL20 靶点信息

CCL20 分子靶点信息概述

  • 分子名：CCL20, C-C motif chemokine ligand 20
  • 基因家族：Chemokine ligands
  • 别名：LARC; MIP-3a; exodus-1; ST38; CKb4
  • 曾用名：SCYA20
  • 全称：small inducible cytokine subfamily A (Cys-Cys), member 20; chemokine (C-C motif) ligand 20

CCL20 分子靶点综述

趋化因子配体20(CCL20)，又名巨噬细胞炎性蛋白3α(MIP-3α)，是CC趋化因子家族的小分子量细胞因子。CCL20对淋巴细胞具有强烈的趋化作用，而对中性粒细胞的趋化作用较弱。单核细胞、巨噬细胞、小胶质细胞、星形胶质细胞、肥大细胞、角质细胞、肠上皮细胞、成骨细胞、成纤维细胞、内皮细胞和支气管上皮细胞都可表达CCL20。CCL20趋化淋巴细胞和树突状细胞到粘膜淋巴组织周围的上皮细胞，从而参与粘膜淋巴组织的形成和功能的发挥。CCL20结合并激活趋化因子受体CCR6来作用于靶细胞。CCL20在中枢神经系统的自身免疫性疾病发病过程中可能起到重要作用。

CCL20, C-C motif chemokine ligand 20 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human CCL20 分子靶点信息

  • 分子名：CCL20, C-C motif chemokine ligand 20
  • 别称：
    • beta chemokine exodus-1
    • beta-chemokine exodus-1
    • C-C motif chemokine 20
    • CC chemokine LARC
    • chemokine (C-C motif) ligand 20
    • CKb4
    • Exodus
    • exodus-1
    • LARC
    • liver and activation-regulated chemokine
    • macrophage inflammatory protein 3 alpha
    • MIP-3-alpha
    • MIP-3a
    • MIP3A
    • SCYA20
    • small inducible cytokine subfamily A (Cys-Cys), member 20
    • small-inducible cytokine A20
    • ST38
  • 基因序列：NCBI_Gene: 6364
  • 蛋白序列：UniProtKB: P78556

人 Human CCL20靶点分子功能（预测）

Enables CCR6 chemokine receptor binding activity. Involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; calcium-mediated signaling using intracellular calcium source; and cell chemotaxis. Acts upstream of or within positive regulation of T cell migration. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Biomarker of several diseases, including IgA glomerulonephritis; Lyme disease; anogenital venereal wart; dermatitis (multiple); and skin papilloma.

小鼠 Mouse Ccl20 分子靶点信息

小鼠 Mouse Ccl20 靶点分子功能（预测）

Enables CCR6 chemokine receptor binding activity and cytokine activity. Involved in chemotaxis and thymocyte migration. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human CCL20 (C-C motif chemokine ligand 20).

大鼠 Rat Ccl20 分子靶点信息

  • 分子名：Ccl20, C-C motif chemokine ligand 20
  • 别称：
    • beta chemokine exodus-1
    • beta-chemokine exodus-1
    • C-C motif chemokine 20
    • CC chemokine LARC
    • CC chemokine ST38
    • chemokine (C-C motif) ligand 20
    • liver and activation-regulated chemokine
    • macrophage inflammatory protein 3 alpha
    • MIP-3-alpha
    • Scya20
    • small inducible cytokine subfamily A20
    • small-inducible cytokine A20
    • ST38
  • 基因序列：NCBI_Gene: 29538
  • 蛋白序列：UniProtKB: P97884

大鼠 Rat Ccl20 靶点分子功能（预测）

Enables chemokine activity. Involved in several processes, including cellular response to molecule of bacterial origin; positive regulation of macromolecule metabolic process; and wound healing. Located in extracellular space. Used to study transient cerebral ischemia. Biomarker of brain ischemia and ulcerative colitis. Orthologous to human CCL20 (C-C motif chemokine ligand 20).

CCL20 分子产品列表

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