文章目录[隐藏]
TNFSF14 分子靶点信息概述
- 分子名：TNFSF14, TNF superfamily member 14
- 基因家族：CD molecules; Tumor necrosis factor superfamily
- 别名：LIGHT; LTg; HVEM-L; CD258
- 全称：tumor necrosis factor (ligand) superfamily, member 14
TNFSF14 分子靶点综述
CD258，又名LIGHT和肿瘤坏死因子超家族成员14 (TNFSF14)，是属于TNF超家族的一种分泌蛋白。它是一种在活化的T细胞和未成熟树突状细胞上表达的II型跨膜蛋白，由疱疹病毒侵入介质(HVEM)和诱骗受体3所识别。该蛋白可作为淋巴细胞活化的共刺激因子和疱疹病毒感染的制止物，能刺激T细胞的增殖、引起多种肿瘤细胞的凋亡和阻止病毒入侵。它同样也被报道可阻止原代肝细胞中TNF α介导的细胞凋亡。另外，CD258还参与T细胞的发育和稳态、树突状细胞的成熟和动脉粥样硬化，在涉及T细胞的疾病如移植物抗宿主病(GVHD)和自身免疫疾病中发挥显著作用。
TNFSF14, TNF superfamily member 14 分子靶点种属信息
人 Human TNFSF14 分子靶点信息
- 分子名：TNFSF14, TNF superfamily member 14
- 别称：
- CD258
- delta transmembrane LIGHT
- herpes virus entry mediator ligand
- herpesvirus entry mediator A
- herpesvirus entry mediator ligand
- herpesvirus entry mediator-ligand
- HVEML
- ligand for herpesvirus entry mediator
- LIGHT
- LTg
- TNLG1D
- TR2
- tumor necrosis factor (ligand) superfamily member 14
- tumor necrosis factor (ligand) superfamily, member 14
- tumor necrosis factor ligand 1D
- tumor necrosis factor ligand superfamily member 14
- tumor necrosis factor receptor-like 2
- tumor necrosis factor superfamily member 14
- tumor necrosis factor superfamily member LIGHT
- 基因序列：NCBI_Gene: 8740
- 蛋白序列：UniProtKB: O43557
人 Human TNFSF14靶点分子功能（预测）
Enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process; identical protein binding activity; and signaling receptor binding activity. Involved in T cell costimulation; cellular response to mechanical stimulus; and positive regulation of NIK/NF-kappaB signaling. Predicted to be located in plasma membrane.
小鼠 Mouse Tnfsf14 分子靶点信息
- 分子名：Tnfsf14, tumor necrosis factor (ligand) superfamily, member 14
- 别称：
- HVEM-L
- LIGHT
- 基因序列：NCBI_Gene: 50930
- 蛋白序列：
小鼠 Mouse Tnfsf14 靶点分子功能（预测）
Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process; identical protein binding activity; and signaling receptor binding activity. Acts upstream of or within several processes, including T cell costimulation; positive regulation of T cell chemotaxis; and positive regulation of myoblast fusion. Predicted to be located in plasma membrane. Used to study IgA glomerulonephritis. Orthologous to human TNFSF14 (TNF superfamily member 14).
大鼠 Rat Tnfsf14 分子靶点信息
- 分子名：Tnfsf14, TNF superfamily member 14
- 别称：
- LOC301133
- similar to Tumor necrosis factor ligand superfamily member 14 (CD258 antigen)
- Tnlg1d
- tumor necrosis factor (ligand) superfamily, member 14
- tumor necrosis factor ligand 1d
- tumor necrosis factor ligand superfamily member 14
- tumor necrosis factor superfamily member 14
- 基因序列：NCBI_Gene: 301133
- 蛋白序列：UniProtKB: M0RCN2
大鼠 Rat Tnfsf14 靶点分子功能（预测）
Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process; identical protein binding activity; and signaling receptor binding activity. Predicted to be involved in cellular response to mechanical stimulus and positive regulation of NIK/NF-kappaB signaling. Predicted to act upstream of or within several processes, including T cell costimulation; positive regulation of T cell chemotaxis; and positive regulation of myoblast fusion. Predicted to be integral component of membrane. Orthologous to human TNFSF14 (TNF superfamily member 14).
