TNFSF13B 靶点信息

TNFSF13B 分子靶点信息概述

  • 分子名：TNFSF13B, TNF superfamily member 13b
  • 基因家族：CD molecules; Tumor necrosis factor superfamily
  • 别名：BAFF; THANK; BLYS; TALL-1; TALL1; CD257
  • 曾用名：TNFSF20
  • 全称：B-cell-activating factor; TNF and ApoL-related leukocyte expressed ligand 1; TNF homolog that activates apoptosis; B-lymphocyte stimulator; tumor necrosis factor (ligand) superfamily, member 13b

TNFSF13B 分子靶点综述

B细胞活化因子(BAFF)也称为B淋巴细胞刺激因子(BLys)或肿瘤坏死因子配体超家族成员13B(TNFSF13B)，表达于B细胞系的细胞，并作为有效的B细胞激活剂，对B细胞的增殖和分化具有重要作用。BAFF在作为免疫刺激剂，是维持正常免疫所必需的。BAFF表达不足会无法活化B细胞产生足够的免疫球蛋白，并导致免疫缺陷。BAFF表达过度会引起抗体分泌量过高，导致系统性红斑狼疮、类风湿性关节炎和其它自身免疫疾病。

TNFSF13B, TNF superfamily member 13b 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human TNFSF13B 分子靶点信息

  • 分子名：TNFSF13B, TNF superfamily member 13b
  • 别称：
    • ApoL related ligand TALL-1
    • b lymphocyte stimulator
    • B-cell activating factor
    • B-cell-activating factor
    • B-lymphocyte stimulator
    • BAFF
    • BLYS
    • CD257
    • delta BAFF
    • Delta4 BAFF
    • dendritic cell-derived TNF-like molecule
    • DTL
    • TALL-1
    • TALL1
    • THANK
    • TNF and ApoL-related leukocyte expressed ligand 1
    • TNF homolog that activates apoptosis
    • TNF- and APOL-related leukocyte expressed ligand 1
    • TNFSF20
    • TNLG7A
    • tumor necrosis factor (ligand) superfamily member 13b
    • tumor necrosis factor (ligand) superfamily, member 13b
    • tumor necrosis factor (ligand) superfamily, member 20
    • tumor necrosis factor ligand 7A
    • tumor necrosis factor ligand superfamily member 13B
    • tumor necrosis factor superfamily member 13b
    • tumor necrosis factor superfamily, member 13b
    • tumor necrosis factor-like protein ZTNF4
    • ZTNF4
  • 基因序列：NCBI_Gene: 10673
  • 蛋白序列：UniProtKB: Q9Y275

人 Human TNFSF13B靶点分子功能（预测）

Predicted to enable receptor ligand activity. Involved in positive regulation of B cell proliferation. Located in several cellular components, including focal adhesion; perinuclear region of cytoplasm; and plasma membrane.

小鼠 Mouse Tnfsf13b 分子靶点信息

小鼠 Mouse Tnfsf13b 靶点分子功能（预测）

Predicted to enable receptor ligand activity. Involved in B cell differentiation and tumor necrosis factor-mediated signaling pathway. Acts upstream of or within B cell homeostasis; positive regulation of germinal center formation; and positive regulation of lymphocyte activation. Predicted to be located in several cellular components, including focal adhesion; perinuclear region of cytoplasm; and plasma membrane. Predicted to be active in extracellular space. Is expressed in genitourinary system. Used to study IgA glomerulonephritis and Sjogren's syndrome. Orthologous to human TNFSF13B (TNF superfamily member 13b).

大鼠 Rat Tnfsf13b 分子靶点信息

大鼠 Rat Tnfsf13b 靶点分子功能（预测）

Predicted to enable receptor ligand activity. Predicted to be involved in B cell differentiation; positive regulation of B cell proliferation; and tumor necrosis factor-mediated signaling pathway. Predicted to act upstream of or within B cell homeostasis; positive regulation of germinal center formation; and positive regulation of lymphocyte activation. Predicted to be located in several cellular components, including focal adhesion; perinuclear region of cytoplasm; and plasma membrane. Predicted to be active in extracellular space. Orthologous to human TNFSF13B (TNF superfamily member 13b).

TNFSF13B 分子产品列表

TNFSF13B 分子靶点最新资讯

人 BAFF（B细胞活化因子）ELISA检测试剂盒