TNFSF12 靶点信息

TNFSF12 分子靶点信息概述

  • 分子名：TNFSF12, TNF superfamily member 12
  • 基因家族：Tumor necrosis factor superfamily
  • 别名：TWEAK; DR3LG; APO3L
  • 全称：tumor necrosis factor (ligand) superfamily, member 12

TNFSF12 分子靶点综述

肿瘤坏死因子样凋亡微弱诱导剂(tumor necrosis factor-like weak inducer of apoptosis, TWEAK) 于 1997 年被发现。TWEAK 基因编码的蛋白是肿瘤坏死因子(TNF)配体家族中的一种细胞因子。白 细胞（包括人静息和活化的单核细胞、树突状细胞和自然杀伤细胞）是 TWEAK 的主要来源。根 据不同的细胞类型，TWEAK 可以通过多种途径诱导细胞凋亡，也能促进内皮细胞的增殖和迁移， 从而起到调节血管生成的作用。在慢性损伤中，过度活化的 TWEAK 通路可以促进病理组织变化， 包括慢性炎症、纤维化和血管生成。

TNFSF12, TNF superfamily member 12 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human TNFSF12 分子靶点信息

  • 分子名：TNFSF12, TNF superfamily member 12
  • 别称：
    • APO3 ligand
    • APO3/DR3 ligand
    • APO3L
    • DR3LG
    • MGC129581
    • MGC20669
    • TNF-related WEAK inducer of apoptosis
    • TNLG4A
    • tumor necrosis factor (ligand) superfamily member 12
    • tumor necrosis factor (ligand) superfamily, member 12
    • tumor necrosis factor ligand 4A
    • tumor necrosis factor ligand superfamily member 12
    • tumor necrosis factor superfamily member 12
    • TWEAK
  • 基因序列：NCBI_Gene: 8742
  • 蛋白序列：UniProtKB: O43508

人 Human TNFSF12靶点分子功能（预测）

Predicted to enable receptor ligand activity. Involved in positive regulation of extrinsic apoptotic signaling pathway. Acts upstream of or within positive regulation of protein catabolic process. Located in perinuclear region of cytoplasm.

小鼠 Mouse Tnfsf12 分子靶点信息

小鼠 Mouse Tnfsf12 靶点分子功能（预测）

Predicted to enable receptor ligand activity. Acts upstream of or within extrinsic apoptotic signaling pathway. Located in extracellular region. Is expressed in Meckel's cartilage; hip; skeleton; and superior cervical ganglion. Orthologous to several human genes including TNFSF12-TNFSF13 (TNFSF12-TNFSF13 readthrough).

大鼠 Rat Tnfsf12 分子靶点信息

大鼠 Rat Tnfsf12 靶点分子功能（预测）

Predicted to enable receptor ligand activity. Predicted to be involved in extrinsic apoptotic signaling pathway and positive regulation of extrinsic apoptotic signaling pathway. Predicted to act upstream of or within positive regulation of protein catabolic process. Predicted to be located in extracellular region and perinuclear region of cytoplasm. Predicted to be active in extracellular space. Orthologous to several human genes including TNFSF12-TNFSF13 (TNFSF12-TNFSF13 readthrough).

TNFSF12 分子产品列表

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