TNFRSF19 靶点信息

TNFRSF19 分子靶点信息概述

  • 分子名：TNFRSF19, TNF receptor superfamily member 19
  • 基因家族：Tumor necrosis factor receptor superfamily
  • 别名：TAJ-alpha; TROY; TAJ; TRADE
  • 全称： tumor necrosis factor receptor superfamily, member 19; toxicity and JNK inducer

TNFRSF19 分子靶点综述

肿瘤坏死因子受体超家族成员19（TNFRSF19），亦称TAJ-α 或TROY，属于TNF受体超家族的一员。在肺上皮细胞以及前列腺=和腮腺的导管上皮细胞中可检测到TNFRSF19/TROY的表达；此外，在源自这些组织的某些腺癌细胞系中也能发现其表达。研究表明，TNFRSF19/TROY能与TRAF家族成员发生相互作用，并且在细胞中过表达时能激活JNK信号通路。该蛋白可通过不依赖于半胱天冬酶的机制诱导细胞凋亡，被认为在胚胎发育过程中起着至关重要的作用。TNFRSF19/TROY的表达受到脂肪生成相关转录因子CCAAT/增强子结合蛋白（C/EBP）的负调控。TNFRSF19能激活JNK信号通路并引发细胞死亡；其过表达还会激活NFB信号通路，其作用机制与p75NGFR类似。TNFRSF19/TROY具备激活TNF受体超家族中关键信号通路的能力，其主要的表达模式表明它在上皮组织的生长与调控中发挥着重要作用。

TNFRSF19 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human TNFRSF19 分子靶点信息

  • 分子名：TNFRSF19, epidermal growth factor receptor
  • 别称：
    • TAJ
    • TAJ-alpha
    • toxicity and JNK inducer
    • TRADE
    • TROY
    • tumor necrosis factor receptor superfamily member 19
    • tumor necrosis factor receptor superfamily, member 19
  • 基因序列：NCBI_Gene: 55504
  • 蛋白序列：UniProtKB: Q9NS68

人 Human TNFRSF19 靶点分子功能（预测）

Predicted to enable signaling receptor activity. Predicted to be involved in positive regulation of JNK cascade and positive regulation of canonical NF-kappaB signal transduction. Predicted to act upstream of or within hair follicle development. Predicted to be located in membrane. Predicted to be active in plasma membrane.

小鼠 Mouse Tnfrsf19 分子靶点信息

小鼠 Mouse Tnfrsf19 靶点分子功能（预测）

Predicted to enable signaling receptor activity. Acts upstream of or within hair follicle development and positive regulation of canonical NF-kappaB signal transduction. Predicted to be located in extracellular region and membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; integumental system; and respiratory system. Orthologous to human TNFRSF19 (TNF receptor superfamily member 19).

大鼠 Rat Tnfrsf19 分子靶点信息

  • 分子名：Tnfrsf19, TNF receptor superfamily member 19
  • 别称：
    • LOC290300
    • RGD1564996
    • similar to tumor necrosis factor receptor superfamily, member 19
    • tumor necrosis factor receptor superfamily member 19
    • tumor necrosis factor receptor superfamily, member 19
  • 基因序列：NCBI_Gene: 290300
  • 蛋白序列：

大鼠 Rat Tnfrsf19 靶点分子功能（预测）

Predicted to enable signaling receptor activity. Predicted to be involved in positive regulation of JNK cascade and positive regulation of canonical NF-kappaB signal transduction. Predicted to act upstream of or within hair follicle development. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human TNFRSF19 (TNF receptor superfamily member 19).

TNFRSF19 分子产品列表

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