文章目录[隐藏]
SEMA4D 分子靶点信息概述
- 分子名：SEMA4D, semaphorin 4D
- 基因家族：Semaphorins; CD molecules; Immunoglobulin like domain containing
- 别名：CD100; coll-4; FLJ39737
- 曾用名：SEMAJ; C9orf164
- 全称：chromosome 9 open reading frame 164; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D; M-sema G
SEMA4D 分子靶点综述
信号素4D（SEMA4D亦称CD100）是信号素蛋白家族成员，在免疫系统、血管系统及神经系统等多类细胞的运动与分化过程中起重要调控作用。VEGF与SEMA4D的表达水平与卵巢癌恶性程度呈正相关，且SEMA4D可作为独立预后判断指标。该蛋白是首个被发现具有免疫调节功能的信号素，在T细胞活化、抗体生成及细胞间黏附中发挥重要作用。SEMA4D通过蛋白水解作用从细胞表面裂解形成的可溶性片段（sSEMA4D），被认为与跨膜形式相似且具备免疫调节特性。
SEMA4D 分子靶点种属信息
人 Human SEMA4D 分子靶点信息
- 分子名：SEMA4D, semaphorin 4D
- 别称：
- A8
- BB18
- C9orf164
- CD100
- chromosome 9 open reading frame 164
- coll-4
- COLL4
- FLJ33485
- FLJ34282
- FLJ39737
- FLJ46484
- GR3
- M-sema-G
- MGC169138
- MGC169141
- sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
- sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, 4D
- SEMAJ
- semaphorin-4D
- 基因序列：NCBI_Gene: 10507
- 蛋白序列：UniProtKB: P92854
人 Human SEMA4D 靶点分子功能（预测）
Enables identical protein binding activity; semaphorin receptor binding activity; and transmembrane signaling receptor activity. Involved in several processes, including positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; regulation of neuron projection development; and regulation of primary metabolic process. Located in microtubule organizing center; nucleoplasm; and plasma membrane.
小鼠 Mouse Sema4d 分子靶点信息
- 分子名：Sema4d, sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
- 别称：
- CD100
- coll-4
- M-sema G
- Semacl2
- Semaj
- semaphorin C-like 2
- semaphorin H
- semaphorin J
- Semcl2
- 基因序列：NCBI_Gene: 20354
- 蛋白序列：
小鼠 Mouse Sema4d 靶点分子功能（预测）
Enables receptor ligand activity and semaphorin receptor binding activity. Involved in several processes, including negative regulation of osteoblast differentiation; positive regulation of Rho protein signal transduction; and positive regulation of inhibitory synapse assembly. Acts upstream of or within positive regulation of axonogenesis. Located in extracellular space. Part of semaphorin receptor complex. Is active in GABA-ergic synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and sensory organ. Orthologous to human SEMA4D (semaphorin 4D).
大鼠 Rat Sema4d 分子靶点信息
- 分子名：Sema4d, semaphorin 4D
- 别称：
- LOC103694042
- LOC306790
- sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
- semaphorin-4D
- uncharacterized LOC103694042
- 基因序列：NCBI_Gene: 306790
- 蛋白序列：
大鼠 Rat Sema4d 靶点分子功能（预测）
Predicted to enable identical protein binding activity; signaling receptor binding activity; and transmembrane signaling receptor activity. Predicted to be involved in several processes, including negative regulation of osteoblast differentiation; positive regulation of intracellular signal transduction; and positive regulation of nervous system development. Predicted to act upstream of or within positive regulation of axonogenesis. Is active in postsynaptic membrane. Orthologous to human SEMA4D (semaphorin 4D).
