S100A1 靶点信息

S100A1 分子靶点信息概述

  • 分子名：S100A1, S100 calcium binding protein A1
  • 基因家族：S100 calcium binding proteins; EF-hand domain containing
  • 别名：S100-alpha
  • 曾用名：S100A
  • 全称：S100 calcium-binding protein A1

S100A1 分子靶点综述

S100A1是一种EF-hand型钙离子结合蛋白，属于S100蛋白家族。该家族包含至少19个成员，以二聚体形式广泛存在于多种细胞的胞质或胞核中，参与调控细胞周期进程和分化等多种生理过程。 S100A1在细胞内Ca2+信号传导和平衡方面扮演关键角色，通过调节细胞内Ca2+的稳定状态来影响肿瘤的增殖和免疫逃避能力。研究表明，S100A1的表达水平与肿瘤的免疫治疗响应密切相关。低表达S100A1的患者通常对免疫治疗反应更好，总生存期更长。此外，S100A1还参与微管组装和蛋白质磷酸化，这些过程对其在细胞内的功能至关重要。

S100A1, epidermal growth factor receptor 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human S100A1 分子靶点信息

  • 分子名：S100A1, S100 calcium binding protein A1
  • 别称：
    • protein S100-A1
    • S-100 protein alpha chain
    • S-100 protein subunit alpha
    • S100
    • S100 alpha
    • S100 calcium-binding protein A1
    • S100 protein, alpha polypeptide
    • S100-alpha
    • S100A
  • 基因序列：NCBI_Gene: 6271
  • 蛋白序列：UniProtKB: P23297

人 Human S100A1 靶点分子功能（预测）

Enables ATPase binding activity; S100 protein binding activity; and protein homodimerization activity. Involved in positive regulation of nitric-oxide synthase activity and positive regulation of sprouting angiogenesis. Located in several cellular components, including Golgi apparatus; nucleoplasm; and sarcoplasmic reticulum.

小鼠 Mouse S100a1 分子靶点信息

小鼠 Mouse S100a1 靶点分子功能（预测）

Predicted to enable several functions, including ATPase binding activity; S100 protein binding activity; and protein homodimerization activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; positive regulation of nitric-oxide synthase activity; and positive regulation of sprouting angiogenesis. Located in sarcoplasmic reticulum. Is expressed in several structures, including brain; heart; inner ear; musculature; and urothelium. Orthologous to human S100A1 (S100 calcium binding protein A1).

大鼠 Rat S100a1 分子靶点信息

  • 分子名：S100a1, S100 calcium binding protein A1
  • 别称：
    • protein S100-A1
    • S-100 protein alpha chain
    • S-100 protein subunit alpha
    • S100 calcium-binding protein A1
  • 基因序列：NCBI_Gene: 295214
  • 蛋白序列：

大鼠 Rat S100a1 靶点分子功能（预测）

Enables calcium ion binding activity; calcium-dependent protein binding activity; and identical protein binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of voltage-gated calcium channel activity. Located in M band and Z disc. Orthologous to human S100A1 (S100 calcium binding protein A1).

S100A1 分子产品列表

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