文章目录[隐藏]
PTPRC 分子靶点信息概述
- 分子名：PTPRC, protein tyrosine phosphatase receptor type C
- 基因家族：CD molecules; Fibronectin type III domain containing; Protein tyrosine phosphatases receptor type
- 别名：LCA; T200; GP180
- 曾用名：CD45
PTPRC 分子靶点综述
CD45也被称为白细胞共同抗原(leukocyte common antigen, LCA)，由一类结构相似，分子量较大(180 kDa、190 kDa、205 kDa和200 kDa)的跨膜蛋白组成，广泛存在于所有白细胞表面(包括淋巴细胞、粒细胞和单核细胞)，但不表达于成熟的红细胞、血小板、骨髓中的成熟红系细胞以及非造血组织。CD45胞浆区段具有蛋白质酪氨酸磷酸酶的作用，能使底物P56lck和P59fyn上酪氨酸脱磷酸而激活，在细胞的信息传导中发挥重要作用，CD45是细胞膜上信号传导的关键分子，在淋巴细胞的发育成熟，功能调节及信号传递中具有重要意义。CD45的分布可作为某些T细胞亚群的分类标志。
PTPRC, protein tyrosine phosphatase receptor type C 分子靶点种属信息
人 Human PTPRC 分子靶点信息
- 分子名：PTPRC, protein tyrosine phosphatase receptor type C
- 别称：
- B220
- CD45
- CD45 antigen
- CD45R
- glycoprotein
- GP180
- L-CA
- LCA
- leukocyte common antigen
- leukocyte-common antigen
- LY5
- protein tyrosine phosphatase, receptor type, c polypeptide
- receptor-type tyrosine-protein phosphatase C
- T200
- T200 glycoprotein
- T200 leukocyte common antigen
- 基因序列：NCBI_Gene: 5788
- 蛋白序列：UniProtKB: P08575
人 Human PTPRC靶点分子功能（预测）
Enables cytoskeletal protein binding activity; protein kinase binding activity; and protein tyrosine phosphatase activity. Involved in several processes, including hematopoietic or lymphoid organ development; positive regulation of cell population proliferation; and regulation of protein kinase activity. Located in bleb and external side of plasma membrane. Implicated in hepatitis C; multiple sclerosis; severe combined immunodeficiency; and severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, Nk cell-positive.
小鼠 Mouse Ptprc 分子靶点信息
- 分子名：Ptprc, protein tyrosine phosphatase, receptor type, C
- 别称：
- B220
- CD45
- Cd45
- CD45 antigen
- Ly-5
- lymphocyte antigen 5
- Lyt-4
- T-lymphocyte antigen 4
- T200
- 基因序列：NCBI_Gene: 19264
- 蛋白序列：
小鼠 Mouse Ptprc 靶点分子功能（预测）
Enables several functions, including heparan sulfate proteoglycan binding activity; heparin binding activity; and protein tyrosine phosphatase activity. Involved in several processes, including lymphocyte differentiation; positive regulation of macromolecule metabolic process; and regulation of signal transduction. Acts upstream of or within several processes, including lymphocyte differentiation; positive regulation of lymphocyte activation; and regulation of protein phosphorylation. Located in external side of plasma membrane; focal adhesion; and membrane raft. Is expressed in several structures, including 3rd branchial arch; alimentary system; cardiovascular system; hemolymphoid system; and placenta. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in hepatitis C; multiple sclerosis; severe combined immunodeficiency; and severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, Nk cell-positive. Orthologous to human PTPRC (protein tyrosine phosphatase receptor type C).
大鼠 Rat Ptprc 分子靶点信息
- 分子名：Ptprc, protein tyrosine phosphatase, receptor type, C
- 别称：
- CD45
- L-CA
- Lca
- leucocyte common antigen
- leukocyte common antigen
- leukocyte common antigen A
- leukocyte common antigen B
- Protein tyrosine phosphatase, receptor-type, c polypeptide
- receptor-type tyrosine-protein phosphatase C
- RT7
- T200
- T200 glycoprotein
- 基因序列：NCBI_Gene: 24699
- 蛋白序列：UniProtKB: P04157
大鼠 Rat Ptprc 靶点分子功能（预测）
Enables protein tyrosine phosphatase activity. Involved in T cell receptor signaling pathway; regulation of gene expression; and response to gamma radiation. Located in cell surface. Is integral component of plasma membrane. Human ortholog(s) of this gene implicated in hepatitis C; multiple sclerosis; severe combined immunodeficiency; and severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, Nk cell-positive. Orthologous to human PTPRC (protein tyrosine phosphatase receptor type C).
