PIGR 靶点信息

PIGR 分子靶点信息概述

  • 分子名：PIGR, polymeric immunoglobulin receptor
  • 基因家族：V-set domain containing
  • 别名：FLJ22667; MGC125361; MGC125362; poly-Ig receptor
  • 曾用名：ERBB
  • 全称：hepatocellular carcinoma associated protein TB6; hepatocellular carcinoma-associated protein TB6

PIGR 分子靶点综述

多聚免疫球蛋白受体（Polymeric immunoglobulin receptor，简称PIGR）是免疫球蛋白超家族成员及Fc受体的一种。该受体胞外域由五个与免疫球蛋白可变区同源的结构单元及一个跨膜区组成，其中跨膜区也与某些免疫球蛋白可变区存在部分同源性。PIGR在肝脏、乳腺等多个腺体上皮组织中均有表达。经推导的氨基酸序列包含764个残基，与兔类及大鼠同源蛋白的总体相似性分别达到56%和64%。该受体介导多聚免疫球蛋白分子的跨细胞运输，从而促进免疫球蛋白A（IgA）和免疫球蛋白M（IgM）的分泌。在此过程中，PIGR会发生裂解，使其胞外段（即分泌成分）与跨膜段分离。

PIGR, polymeric immunoglobulin receptor 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human PIGR 分子靶点信息

  • 分子名：PIGR, polymeric immunoglobulin receptor
  • 别称：
    • FLJ22667
    • hepatocellular carcinoma associated protein TB6
    • hepatocellular carcinoma-associated protein TB6
    • MGC125361
    • MGC125362
    • poly-Ig receptor
  • 基因序列：NCBI_Gene: 5284
  • 蛋白序列：UniProtKB: P01833

人 Human PIGR靶点分子功能（预测）

Enables polymeric immunoglobulin binding activity and polymeric immunoglobulin receptor activity. Involved in several processes, including cell surface receptor signaling pathway; detection of chemical stimulus involved in sensory perception of bitter taste; and immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor. Located in extracellular space and plasma membrane. Part of receptor complex and secretory IgA immunoglobulin complex.

小鼠 Mouse Pigr 分子靶点信息

小鼠 Mouse Pigr 靶点分子功能（预测）

Predicted to enable epidermal growth factor receptor binding activity; polymeric immunoglobulin binding activity; and polymeric immunoglobulin receptor activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; detection of chemical stimulus involved in sensory perception of bitter taste; and immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor. Predicted to be located in extracellular space and recycling endosome membrane. Predicted to be part of receptor complex and secretory IgA immunoglobulin complex. Predicted to be active in plasma membrane. Is expressed in large intestine and small intestine. Orthologous to human PIGR (polymeric immunoglobulin receptor).

大鼠 Rat Pigr 分子靶点信息

  • 分子名：Pigr, polymeric immunoglobulin receptor
  • 别称：
    • pIgA-R
    • poly-Ig receptor
    • polymeric IgA receptor
    • RNPIGR2
  • 基因序列：NCBI_Gene: 25046
  • 蛋白序列：

大鼠 Rat Pigr 靶点分子功能（预测）

Enables epidermal growth factor receptor binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; detection of chemical stimulus involved in sensory perception of bitter taste; and immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor. Located in recycling endosome membrane. Orthologous to human PIGR (polymeric immunoglobulin receptor).

PIGR 分子产品列表

PIGR 分子靶点最新资讯