PDGFRB 靶点信息

PDGFRB 分子靶点信息概述

  • 分子名：PDGFRB, platelet derived growth factor receptor beta
  • 基因家族：Receptor tyrosine kinases; CD molecules; I-set domain containing
  • 别名：JTK12; CD140b; PDGFR1
  • 曾用名：PDGFR
  • 全称：platelet-derived growth factor receptor, beta polypeptide

PDGFRB 分子靶点综述

血小板衍生生长因子受体β (PDGFRB)，又名CD140b，和结构同源蛋白PDGFRA (CD140a)都是受体酪氨酸激酶(RTK) III类亚家族中的成员，这个亚家族还包括M-CSF、SCF和Flt-3配体的受体。所有的III类RTKs的胞外区都含有5个免疫球蛋白样结构域，胞内区则含有1个激酶结构域。PDGF是一种重要的血清有丝分裂原，可通过二硫键连接PDGF-A链和PDGF-B链，形成同源或异源二聚体蛋白。PDGFRA和PDGFRB以不同的亲和力结合PDGF-AA、PDGF-BB和PDGF-AB异构体，其中PDGFRA可高亲和力结合PDGF的3个异构体，而PDGFRB只可高亲和力结合PDGF-BB。PDGF结合可诱导受体同源和异源二聚体化及信号转导。PDGFRA和PDGFRB在多种细胞类型中独立调节。重组的可溶性PDGFRB可高亲和力结合PDGF，是一种有效的PDGF拮抗剂。

PDGFRB, platelet derived growth factor receptor beta 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human PDGFRB 分子靶点信息

  • 分子名：PDGFRB, platelet derived growth factor receptor beta
  • 别称：
    • Activated tyrosine kinase PDGFRB
    • beta-type platelet-derived growth factor receptor
    • CD140 antigen-like family member B
    • CD140B
    • IBGC4
    • IMF1
    • JTK12
    • KOGS
    • NDEL1-PDGFRB
    • PDGF-R-beta
    • PDGFR
    • PDGFR-1
    • PDGFR-beta
    • PDGFR1
    • PENTT
    • platelet-derived growth factor receptor 1
    • platelet-derived growth factor receptor beta
    • platelet-derived growth factor receptor, beta polypeptide
  • 基因序列：NCBI_Gene: 5159
  • 蛋白序列：UniProtKB: P09619

人 Human PDGFRB靶点分子功能（预测）

Enables several functions, including growth factor binding activity; platelet-derived growth factor beta-receptor activity; and platelet-derived growth factor receptor binding activity. Involved in several processes, including platelet-derived growth factor receptor signaling pathway; positive regulation of phosphate metabolic process; and protein phosphorylation. Located in Golgi apparatus and membrane. Is intrinsic component of plasma membrane. Implicated in basal ganglia calcification; glioblastoma; infantile myofibromatosis; myeloproliferative neoplasm (multiple); and renal cell carcinoma. Biomarker of Kuhnt-Junius degeneration; breast cancer (multiple); renal cell carcinoma; and reproductive organ cancer (multiple).

小鼠 Mouse Pdgfrb 分子靶点信息

小鼠 Mouse Pdgfrb 靶点分子功能（预测）

Enables platelet-derived growth factor-activated receptor activity and signaling receptor binding activity. Involved in several processes, including positive regulation of intracellular signal transduction; protein phosphorylation; and vasculature development. Acts upstream of or within several processes, including animal organ development; response to ceramide; and ruffle assembly. Located in cell surface; cytoplasm; and ruffle. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; nervous system; and sensory organ. Used to study basal ganglia calcification; infantile myofibromatosis; myeloproliferative neoplasm; and severe nonproliferative diabetic retinopathy. Human ortholog(s) of this gene implicated in basal ganglia calcification; glioblastoma; infantile myofibromatosis; myeloproliferative neoplasm (multiple); and renal cell carcinoma. Orthologous to human PDGFRB (platelet derived growth factor receptor beta).

大鼠 Rat Pdgfrb 分子靶点信息

  • 分子名：Pdgfrb, platelet derived growth factor receptor beta
  • 别称：
    • beta platelet-derived growth factor receptor
    • beta-type platelet-derived growth factor receptor
    • CD140 antigen-like family member B
    • PDGF-R-beta
    • PDGFR-1
    • PDGFR-beta
    • platelet derived growth factor receptor, beta polypeptide
    • platelet-derived growth factor receptor 1
    • Platelet-derived growth factor receptor beta
    • platelet-derived growth factor receptor beta variant 1
    • Platelet-derived growth factor receptor, beta
  • 基因序列：NCBI_Gene: 24629
  • 蛋白序列：UniProtKB: Q05030

大鼠 Rat Pdgfrb 靶点分子功能（预测）

Enables phosphatidylinositol 3-kinase binding activity and platelet-derived growth factor-activated receptor activity. Involved in several processes, including animal organ development; positive regulation of Rho protein signal transduction; and regulation of apoptotic process. Located in several cellular components, including apical plasma membrane; cell surface; and nucleus. Used to study extrahepatic cholestasis; middle cerebral artery infarction; and prostate cancer. Biomarker of hypertension; oligohydramnios; and sciatic neuropathy. Human ortholog(s) of this gene implicated in basal ganglia calcification; glioblastoma; infantile myofibromatosis; myeloproliferative neoplasm (multiple); and renal cell carcinoma. Orthologous to human PDGFRB (platelet derived growth factor receptor beta).

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