NTRK2 靶点信息

NTRK2 分子靶点信息概述

  • 分子名：NTRK2, neurotrophic receptor tyrosine kinase 2
  • 基因家族：Receptor tyrosine kinases; I-set domain containing
  • 别名：TRKB
  • 全称：BDNF/NT-3 growth factors receptor; neurotrophic tyrosine kinase, receptor, type 2

NTRK2 分子靶点综述

原肌球蛋白激酶受体B (TrkB)，又名酪氨酸激酶受体B，是脑源性神经营养因子(BDNF)的受体，是神经营养因子酪氨酸激酶受体(NTRK)家族中的一员。这个激酶是一种只在中枢神经系统的神经元中表达的膜结合受体。TrkB介导神经营养因子如BDNF、神经营养因子-4 (NT-4)和神经营养因子-3 (NT-3)的许多作用功能，包括神经元的分化和存活。在胞外结构域中，它有两个不同的可高亲和力结合BDNF的区域。一旦结合神经营养因子，TrkB自身以及相关信号途径的下游分子成员就会发生磷酸化。 TrkB在肿瘤发生和转移中发挥重要的作用，该基因突变与肥胖和情绪障碍有关。因此，BDNF/TrkB信号被认为是治疗精神分裂症的一种潜在靶点。

NTRK2, neurotrophic receptor tyrosine kinase 2 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human NTRK2 分子靶点信息

  • 分子名：NTRK2, neurotrophic receptor tyrosine kinase 2
  • 别称：
    • BDNF-tropomyosine receptor kinase B
    • BDNF/NT-3 growth factors receptor
    • DEE58
    • EIEE58
    • GP145-TrkB
    • neurotrophic tyrosine kinase receptor type 2
    • neurotrophic tyrosine kinase, receptor, type 2
    • neurotrophic tyrosine receptor kinase type 2
    • OBHD
    • trk-B
    • TRKB
    • trkB tyrosine kinase
    • tropomyosin-related kinase B
    • tyrosine kinase receptor B
  • 基因序列：NCBI_Gene: 4915
  • 蛋白序列：UniProtKB: Q16620

人 Human NTRK2靶点分子功能（预测）

Enables brain-derived neurotrophic factor-activated receptor activity; neurotrophin binding activity; and protease binding activity. Involved in brain-derived neurotrophic factor receptor signaling pathway. Acts upstream of or within negative regulation of amyloid-beta formation. Is integral component of plasma membrane. Part of receptor complex. Implicated in Alzheimer's disease; autistic disorder; developmental and epileptic encephalopathy 58; major depressive disorder; and morbid obesity. Biomarker of bipolar disorder; idiopathic pulmonary fibrosis; major depressive disorder; and schizophrenia.

小鼠 Mouse Ntrk2 分子靶点信息

小鼠 Mouse Ntrk2 靶点分子功能（预测）

Enables brain-derived neurotrophic factor binding activity and brain-derived neurotrophic factor-activated receptor activity. Involved in several processes, including brain-derived neurotrophic factor receptor signaling pathway; nervous system development; and trans-synaptic signaling, modulating synaptic transmission. Acts upstream of or within several processes, including neurogenesis; neuronal action potential propagation; and positive regulation of peptidyl-serine phosphorylation. Located in several cellular components, including early endosome; postsynaptic density; and postsynaptic membrane. Is expressed in several structures, including alimentary system; cardiovascular system; future brain; genitourinary system; and nervous system. Human ortholog(s) of this gene implicated in Alzheimer's disease; autistic disorder; developmental and epileptic encephalopathy 58; major depressive disorder; and morbid obesity. Orthologous to human NTRK2 (neurotrophic receptor tyrosine kinase 2).

大鼠 Rat Ntrk2 分子靶点信息

  • 分子名：Ntrk2, neurotrophic receptor tyrosine kinase 2
  • 别称：
    • BDNF/NT-3 growth factors receptor
    • GP145-TrkB/GP95-TrkB
    • Neural receptor protein-tyrosine kinase (trkB)
    • neurotrophic tyrosine kinase, receptor, type 2
    • neurotrophic tyrosine receptor kinase type 2
    • RATTRKB1
    • Tkrb
    • trk-B
    • trkB
    • trkB tyrosine kinase
    • TRKB1
  • 基因序列：NCBI_Gene: 25054
  • 蛋白序列：

大鼠 Rat Ntrk2 靶点分子功能（预测）

Enables several functions, including brain-derived neurotrophic factor binding activity; brain-derived neurotrophic factor-activated receptor activity; and protein homodimerization activity. Involved in several processes, including brain-derived neurotrophic factor receptor signaling pathway; positive regulation of cell communication; and regulation of neuron projection development. Acts upstream of or within positive regulation of glucocorticoid receptor signaling pathway. Located in several cellular components, including distal axon; perikaryon; and postsynaptic density. Is integral component of plasma membrane. Is active in glutamatergic synapse and postsynapse. Used to study glaucoma. Biomarker of several diseases, including attention deficit hyperactivity disorder; colitis; mental depression; post-traumatic stress disorder; and temporal lobe epilepsy. Human ortholog(s) of this gene implicated in Alzheimer's disease; autistic disorder; developmental and epileptic encephalopathy 58; major depressive disorder; and morbid obesity. Orthologous to human NTRK2 (neurotrophic receptor tyrosine kinase 2).

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