NTRK1 靶点信息

NTRK1 分子靶点信息概述

  • 分子名：NTRK1, neurotrophic receptor tyrosine kinase 1
  • 基因家族：Receptor tyrosine kinases; Immunoglobulin like domain containing
  • 别名：TRK; TRKA; MTC
  • 曾用名：neurotrophic tyrosine kinase, receptor, type 1
  • 全称：high affinity nerve growth factor receptor; tropomyosin receptor kinase A

NTRK1 分子靶点综述

TrkA（Tyrosine kinase receptor ，酪氨酸激酶受体A）是原癌基因Trk的产物，是神经营养酪氨酸激酶受体家族的成员，也被称为高亲和力神经生长因子受体1（NTRK1）。TrkA、TrkB和TrkC分别优先结合NGF、NT-4和BDNF、NT-3。所有Trk家族蛋白都有一个保守的复杂亚结构域组织，包括一个信号肽，两个富含半胱氨酸的结构域，三个富含亮氨酸的基序，细胞外区域的两个类似免疫球蛋白的结构域，以及一个包含酪氨酸激酶结构域的细胞内区域。两种不同的TrkA异构体因其胞外结构域的6个氨基酸插入而不同。较长的TrkA亚型是唯一在神经元组织中表达的亚型，而较短的TrkA主要在非神经元组织中表达。NGF以低亲和力与TrkA结合并激活其细胞质激酶，启动一个介导神经元存活和分化的信号级联。NGF的高亲和力结合需要TrkA与肿瘤坏死因子受体超家族成员之一的p75 NGF受体 (NGFR) 共表达。NGFR以低亲和力结合所有神经营养因子，调节Trk活性，并改变Trk受体对其配体的特异性。

NTRK1, neurotrophic receptor tyrosine kinase 1 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human NTRK1 分子靶点信息

  • 分子名：NTRK1, neurotrophic receptor tyrosine kinase 1
  • 别称：
    • DKFZp781I14186
    • gp140trk
    • high affinity nerve growth factor receptor
    • MTC
    • neurotrophic tyrosine kinase, receptor, type 1
    • Oncogene TRK
    • p140-TrkA
    • TRK
    • trk precursor
    • Trk-A
    • TRK1
    • TRK1-transforming tyrosine kinase protein
    • TRKA
    • tropomyosin receptor kinase A
    • tropomyosin-related kinase A
    • tyrosine kinase receptor A
  • 基因序列：NCBI_Gene: 4914
  • 蛋白序列：UniProtKB: P04629

人 Human NTRK1靶点分子功能（预测）

Enables several functions, including nerve growth factor binding activity; nerve growth factor receptor activity; and protein homodimerization activity. Involved in several processes, including neurotrophin signaling pathway; positive regulation of intracellular signal transduction; and protein phosphorylation. Acts upstream of or within neuron projection development and peptidyl-tyrosine autophosphorylation. Located in plasma membrane. Part of receptor complex. Implicated in Alzheimer's disease; hereditary sensory neuropathy; hereditary sensory neuropathy type 4; and schizophrenia. Biomarker of several diseases, including Hirschsprung's disease; lung disease (multiple); neuroblastoma; obstructive sleep apnea; and rhinitis.

小鼠 Mouse Ntrk1 分子靶点信息

  • 分子名：Ntrk1, neurotrophic tyrosine kinase, receptor, type 1
  • 别称：
    • C80751
    • expressed sequence C80751
    • Tkr
    • Trk
    • TrkA
    • tyrosine kinase receptor proto-oncogene
  • 基因序列：NCBI_Gene: 18211
  • 蛋白序列：

小鼠 Mouse Ntrk1 靶点分子功能（预测）

Predicted to enable several functions, including GPI-linked ephrin receptor activity; nerve growth factor binding activity; and nerve growth factor receptor activity. Involved in circadian rhythm; negative regulation of neuron apoptotic process; and nervous system development. Acts upstream of or within several processes, including behavioral response to formalin induced pain; nerve growth factor signaling pathway; and nervous system development. Located in axon; cell surface; and endosome. Part of protein-containing complex. Is expressed in several structures, including branchial arch; nervous system; reproductive system; sensory organ; and trunk. Used to study hereditary sensory neuropathy. Human ortholog(s) of this gene implicated in Alzheimer's disease; hereditary sensory neuropathy; hereditary sensory neuropathy type 4; and schizophrenia. Orthologous to human NTRK1 (neurotrophic receptor tyrosine kinase 1).

大鼠 Rat Ntrk1 分子靶点信息

  • 分子名：Ntrk1, neurotrophic receptor tyrosine kinase 1
  • 别称：
    • high affinity nerve growth factor receptor
    • neurotrophic tyrosine kinase, receptor, type 1
    • p140-TrkA
    • slow nerve growth factor receptor
    • Trk
    • trk precursor
    • trk-A
    • TrkA neurotrophin receptor
    • trkA proto-oncogene receptor
    • tropomyosin-related kinase A
  • 基因序列：NCBI_Gene: 59109
  • 蛋白序列：

大鼠 Rat Ntrk1 靶点分子功能（预测）

Enables several functions, including GPI-linked ephrin receptor activity; nerve growth factor binding activity; and neurotrophin p75 receptor binding activity. Involved in several processes, including detection of stimulus involved in sensory perception of pain; nervous system development; and positive regulation of cell communication. Acts upstream of or within cellular response to growth factor stimulus and protein autophosphorylation. Located in several cellular components, including cell surface; endosome; and neuronal cell body. Part of protein-containing complex. Used to study Parkinsonism; glaucoma; and myofascial pain syndrome. Biomarker of several diseases, including colitis; diabetic neuropathy; glaucoma; periodontitis; and retinal detachment. Human ortholog(s) of this gene implicated in Alzheimer's disease; hereditary sensory neuropathy; hereditary sensory neuropathy type 4; and schizophrenia. Orthologous to human NTRK1 (neurotrophic receptor tyrosine kinase 1).

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