NGF 靶点信息

NGF 分子靶点信息概述

  • 分子名：NGF, nerve growth factor
  • 基因家族：Neurotrophins
  • 曾用名：NGFB
  • 全称：nerve growth factor (beta polypeptide)

NGF 分子靶点综述

神经生长因子(NGF)是一种神经肽，主要参与调节某些靶神经元的生长、增殖和存活。当表达时，NGF最初是以7S、分子量为130kDa的复合物存在，这个复合物由α-NGF、β-NGF和γ-NGF(2:1:2比例)三个蛋白组成。“神经生长因子”通常指的是2.5S、分子量为26kDa的β亚基蛋白。β亚基是7SNGF复合物中唯一一个有生物活性的成分(如作为信号分子)。NGF在先天性和获得性免疫中都起着重要作用。研究表明NGF通过血浆在机体中循环，对整体的稳态维持很重要。NGF可促进髓鞘的修复，亦可参与多种精神疾病，如老年痴呆症、抑郁症、精神分裂症、自闭症、雷特综合征、神经性厌食症，神经性贪食症。NGF信号失调与阿尔茨海默病有关。同样，NGF在许多心血管疾病中发挥作用，如冠状动脉粥样硬化、肥胖、2型糖尿病、代谢综合征。NGF也可促进伤口愈合。

NGF, nerve growth factor 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human NGF 分子靶点信息

  • 分子名：NGF, nerve growth factor
  • 别称：
    • beta-nerve growth factor
    • Beta-NGF
    • HSAN5
    • MGC161426
    • MGC161428
    • nerve growth factor (beta polypeptide)
    • nerve growth factor, beta polypeptide
    • nerve growth factor, beta subunit
    • NGFB
    • pro-nerve growth factor long
  • 基因序列：NCBI_Gene: 4803
  • 蛋白序列：UniProtKB: P01138

人 Human NGF靶点分子功能（预测）

Enables peptidase regulator activity and signaling receptor binding activity. Involved in extrinsic apoptotic signaling pathway via death domain receptors; neuron apoptotic process; and positive regulation of macromolecule metabolic process. Acts upstream of or within neuron projection morphogenesis. Predicted to be located in neuron projection terminus. Predicted to be active in several cellular components, including axon; dendrite; and synaptic vesicle. Implicated in IgA glomerulonephritis; asthma; end stage renal disease; hereditary sensory and autonomic neuropathy type 5; and interstitial cystitis. Biomarker of several diseases, including artery disease (multiple); interstitial cystitis; lung disease (multiple); neurogenic bladder; and obstructive sleep apnea.

小鼠 Mouse Ngf 分子靶点信息

小鼠 Mouse Ngf 靶点分子功能（预测）

Enables transmembrane receptor protein tyrosine kinase activator activity. Involved in positive regulation of DNA binding activity; positive regulation of Ras protein signal transduction; and positive regulation of protein phosphorylation. Acts upstream of or within several processes, including cell surface receptor signaling pathway; positive regulation of cell projection organization; and positive regulation of macromolecule metabolic process. Located in neuron projection terminus. Is expressed in several structures, including alimentary system; genitourinary system; limb; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; end stage renal disease; hereditary sensory and autonomic neuropathy type 5; interstitial cystitis; and neurogenic bladder. Orthologous to human NGF (nerve growth factor).

大鼠 Rat Ngf 分子靶点信息

  • 分子名：Ngf, nerve growth factor
  • 别称：
    • beta-nerve growth factor
    • beta-NGF
    • nerve growth factor (beta polypeptide)
    • nerve growth factor, beta
    • nerve growth factor, beta (mapped)
    • Ngfb
    • Ngfb_mapped
    • pro-nerve growth factor long
  • 基因序列：NCBI_Gene: 310738
  • 蛋白序列：

大鼠 Rat Ngf 靶点分子功能（预测）

Predicted to enable nerve growth factor receptor binding activity; peptidase regulator activity; and signaling receptor activator activity. Involved in several processes, including negative regulation of apoptotic process; positive regulation of ERK1 and ERK2 cascade; and response to ozone. Acts upstream of or within positive regulation of DNA-binding transcription factor activity; positive regulation of neurotrophin TRK receptor signaling pathway; and positive regulation of protein autophosphorylation. Located in extracellular space. Used to study bladder neck obstruction; cystitis; degenerative disc disease; and neurogenic bladder. Biomarker of several diseases, including diabetic neuropathy; hyperhomocysteinemia; mental depression; myofascial pain syndrome; and respiratory syncytial virus infectious disease. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; asthma; end stage renal disease; hereditary sensory and autonomic neuropathy type 5; and interstitial cystitis. Orthologous to human NGF (nerve growth factor).

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