MMP7 靶点信息

MMP7 分子靶点信息概述

  • 分子名：MMP7, matrix metallopeptidase 7
  • 基因家族：M10 matrix metallopeptidases
  • 别名：PUMP-1
  • 曾用名：MPSL1
  • 全称：matrilysin; matrix metalloproteinase 7 (matrilysin, uterine)

MMP7 分子靶点综述

基质金属蛋白酶7(MMP-7)，又名基质溶解素，在人类中由MMP7基因编码。MMP-7通常在上皮细胞、肝脏和乳腺中表达。MMP-7的表达受Wnt/β联蛋白信号途径调控，受转化生长因子β(TGF-β)介导。裂解的/活化的MMP-7的主要作用是通过降解大分子包括酪蛋白、I、II、IV和V型明胶、纤维连接蛋白和蛋白聚糖来分解细胞外基质。MMP-7可能参与肿瘤转移和炎症过程。上调的MMP-7与许多恶性肿瘤包括食道、胃、结肠、肝脏、胰腺和肾细胞癌有关。MMP-7在重度发育异常的晚期结直肠腺瘤性息肉中高度表达，此外，它参与结直肠腺瘤转化为恶性状态并促进其生长。

MMP7, matrix metallopeptidase 7 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human MMP7 分子靶点信息

  • 分子名：MMP7, matrix metallopeptidase 7
  • 别称：
    • matrilysin
    • matrin
    • matrix metallopeptidase 7 (matrilysin, uterine)
    • matrix metalloproteinase 7
    • matrix metalloproteinase 7 (matrilysin, uterine)
    • matrix metalloproteinase-7
    • MMP-7
    • MPSL1
    • PUMP-1
    • pump-1 protease
    • uterine matrilysin
    • uterine metalloproteinase
  • 基因序列：NCBI_Gene: 4316
  • 蛋白序列：UniProtKB: P09237

人 Human MMP7靶点分子功能（预测）

Enables endopeptidase activity and metallopeptidase activity. Involved in positive regulation of cell migration and proteolysis. Acts upstream of or within membrane protein ectodomain proteolysis and membrane protein intracellular domain proteolysis. Located in extracellular exosome. Biomarker of endometrial cancer; endometrial hyperplasia; glioblastoma; and lung non-small cell carcinoma.

小鼠 Mouse Mmp7 分子靶点信息

小鼠 Mouse Mmp7 靶点分子功能（预测）

Enables peptidase activity. Acts upstream of or within several processes, including defense response to bacterium; proteolysis; and response to xenobiotic stimulus. Predicted to be located in cell surface. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; hemolymphoid system gland; integumental system; liver and biliary system; and reproductive system. Orthologous to human MMP7 (matrix metallopeptidase 7).

大鼠 Rat Mmp7 分子靶点信息

  • 分子名：Mmp7, matrix metallopeptidase 7
  • 别称：
    • matrilysin
    • matrin
    • matrix metalloproteinase 7
    • Matrix metalloproteinase 7 (matrilysin)
    • matrix metalloproteinase-7
    • MMP-7
    • MPMM
    • pump-1 protease
    • uterine metalloproteinase
  • 基因序列：NCBI_Gene: 25335
  • 蛋白序列：UniProtKB: P50280

大鼠 Rat Mmp7 靶点分子功能（预测）

Enables heparin binding activity. Involved in several processes, including cellular response to mechanical stimulus; estrous cycle; and maternal process involved in female pregnancy. Located in cell surface and extracellular space. Used to study hypertension and prostate carcinoma. Biomarker of bladder neck obstruction; coronary restenosis; hypertension; prostate cancer; and renal hypertension. Orthologous to human MMP7 (matrix metallopeptidase 7).

MMP7 分子产品列表

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