IL2RG 靶点信息

IL2RG 分子靶点信息概述

  • 分子名：IL2RG, interleukin 2 receptor subunit gamma
  • 基因家族：Interleukin receptors; Fibronectin type III domain containing; CD molecules
  • 别名：CD132
  • 曾用名：SCIDX1; IMD4; CIDX
  • 全称：severe combined immunodeficiency; combined immunodeficiency, X-linked; interleukin 2 receptor, gamma

IL2RG 分子靶点综述

共同γ链（γc）（又称CD132），全称为白细胞介素-2受体γ亚基（IL2RG），是I型细胞因子受体家族成员，在大多数淋巴细胞（白细胞）群体中均有表达，其基因位于哺乳动物X染色体上。作为细胞因子受体的共同亚基，γc至少参与六种白细胞介素受体复合物的构成：IL-2、IL-4、IL-7、IL-9、IL-15以及白细胞介素-21受体。该蛋白是多种细胞因子受体的关键组分，对淋巴细胞发育和功能至关重要。
X连锁重症联合免疫缺陷症（X-SCID）是一种罕见且可能致命的疾病，由编码IL2RG的基因突变所致。基于化学交联实验数据，IL2RG被证实是IL-4受体的组成成分，其能够增强IL-4的结合亲和力。研究发现IL-2Rγ不仅是IL-4受体的功能性组分，还与IL-7受体存在相互作用，这解释了为何γc链缺陷会如X连锁重症联合免疫缺陷症所表现的那样，对淋巴系统功能和发育产生深远影响。

IL2RG, interleukin 2 receptor subunit gamma 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human IL2RG 分子靶点信息

  • 分子名：IL2RG, interleukin 2 receptor subunit gamma
  • 别称：
    • CD132
    • CD132 antigen
    • CIDX
    • combined immunodeficiency, X-linked
    • common cytokine receptor gamma chain
    • common gamma-chain
    • cytokine receptor common subunit gamma
    • gamma(c)
    • gammaC
    • IL-2 receptor subunit gamma
    • IL-2R subunit gamma
    • IL-2RG
    • IMD4
    • interleukin 2 receptor, gamma
    • interleukin 2 receptor, gamma (severe combined immunodeficiency)
    • interleukin 2 receptor, gamma chain
    • interleukin-2 receptor subunit gamma
    • nonfunctional common cytokine receptor gamma chain
    • P64
    • SCIDX
    • SCIDX1
    • severe combined immunodeficiency
  • 基因序列：NCBI_Gene: 3561
  • 蛋白序列：UniProtKB: P31785

人 Human IL2RG 靶点分子功能（预测）

Enables coreceptor activity and interleukin-15 receptor activity. Involved in cellular homeostasis; cytokine-mediated signaling pathway; and positive regulation of phagocytosis. Located in cell surface and nucleoplasm. Is active in plasma membrane. Implicated in X-linked severe combined immunodeficiency; combined T cell and B cell immunodeficiency; and severe combined immunodeficiency. Biomarker of COVID-19.

小鼠 Mouse Il2rg 分子靶点信息

小鼠 Mouse Il2rg 靶点分子功能（预测）

Enables interleukin-2 binding activity. Acts upstream of or within positive regulation of gene expression and positive regulation of lymphocyte differentiation. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and liver and biliary system. Human ortholog(s) of this gene implicated in X-linked severe combined immunodeficiency; combined T cell and B cell immunodeficiency; and severe combined immunodeficiency. Orthologous to human IL2RG (interleukin 2 receptor subunit gamma).

大鼠 Rat Il2rg 分子靶点信息

大鼠 Rat Il2rg 靶点分子功能（预测）

Predicted to enable coreceptor activity; interleukin-15 receptor activity; and interleukin-2 binding activity. Predicted to be involved in cellular homeostasis; cytokine-mediated signaling pathway; and positive regulation of phagocytosis. Predicted to act upstream of or within positive regulation of gene expression and positive regulation of lymphocyte differentiation. Predicted to be located in external side of plasma membrane and nucleoplasm. Predicted to be active in plasma membrane. Used to study X-linked severe combined immunodeficiency and combined T cell and B cell immunodeficiency. Human ortholog(s) of this gene implicated in X-linked severe combined immunodeficiency; combined T cell and B cell immunodeficiency; and severe combined immunodeficiency. Orthologous to human IL2RG (interleukin 2 receptor subunit gamma).

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