IL21 靶点信息

IL21 分子靶点信息概述

  • 分子名：IL21, interleukin 21
  • 基因家族：Interleukins
  • 别名：Za11; IL-21

IL21 分子靶点综述

白细胞介素21(IL-21)对免疫细胞具有强烈的调节作用，包括可破坏病毒感染或肿瘤细胞的自然杀伤细胞(NK)和细胞毒性T细胞。该细胞因子可诱导靶细胞分裂/增殖。IL-21表达于人活化的CD4+T细胞，但在其他大多数组织中并没有表达。此外，IL-21在辅助性T细胞亚群Th2和Th17细胞以及滤泡性T细胞中表达上调。而且IL-21还表达于调控这些细胞功能的NKT细胞中。IL-21在免疫炎性疾病中具有病理作用。研究表明存在一个正向自分泌环，可放大并稳定IL-21驱使的、T细胞介导的应答。而且，它还具有抗肿瘤活性，对自身免疫进程具有作用。在临床上，IL-21还可作为潜在的抗肿瘤药物。

IL21, interleukin 21 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human IL21 分子靶点信息

  • 分子名：IL21, interleukin 21
  • 别称：
    • CVID11
    • IL-21
    • interleukin-21
    • interleukin-21 isoform
    • Za11
  • 基因序列：NCBI_Gene: 59067
  • 蛋白序列：UniProtKB: Q9HBE4

人 Human IL21靶点分子功能（预测）

Enables interleukin-2 receptor binding activity. Involved in several processes, including positive regulation of interleukin-17 production; positive regulation of natural killer cell mediated cytotoxicity; and tyrosine phosphorylation of STAT protein. Acts upstream of or within positive regulation of B cell proliferation; positive regulation of T cell proliferation; and positive regulation of tyrosine phosphorylation of STAT protein. Predicted to be located in extracellular region. Implicated in asthma; common variable immunodeficiency; hepatocellular carcinoma; and systemic lupus erythematosus. Biomarker of several diseases, including anogenital venereal wart; autoimmune disease (multiple); dengue hemorrhagic fever; human immunodeficiency virus infectious disease; and tropical spastic paraparesis.

小鼠 Mouse Il21 分子靶点信息

小鼠 Mouse Il21 靶点分子功能（预测）

Enables cytokine receptor binding activity. Involved in cellular response to virus; lymphocyte activation involved in immune response; and positive regulation of immunoglobulin production. Acts upstream of or within positive regulation of cytokine production; positive regulation of natural killer cell differentiation; and positive regulation of natural killer cell mediated cytotoxicity. Predicted to be located in extracellular space. Is expressed in ductus deferens; epididymis; and testis. Human ortholog(s) of this gene implicated in asthma; common variable immunodeficiency; hepatocellular carcinoma; and systemic lupus erythematosus. Orthologous to human IL21 (interleukin 21).

大鼠 Rat Il21 分子靶点信息

大鼠 Rat Il21 靶点分子功能（预测）

Predicted to enable interleukin-2 receptor binding activity. Predicted to be involved in several processes, including lymphocyte activation involved in immune response; positive regulation of immune effector process; and tyrosine phosphorylation of STAT protein. Predicted to act upstream of or within positive regulation of cytokine production; positive regulation of lymphocyte activation; and positive regulation of tyrosine phosphorylation of STAT protein. Predicted to be located in extracellular space. Biomarker of periodontal disease. Human ortholog(s) of this gene implicated in asthma; common variable immunodeficiency; hepatocellular carcinoma; and systemic lupus erythematosus. Orthologous to human IL21 (interleukin 21).

IL21 分子产品列表

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