IL1R1 靶点信息

IL1R1 分子靶点信息概述

  • 分子名：IL1R1, interleukin 1 receptor type 1
  • 基因家族：I-set domain containing; Interleukin receptors; TIR domain containing; CD molecules
  • 别名：D2S1473; CD121A
  • 曾用名：IL1R; IL1RA
  • 全称：interleukin 1 receptor, type I; interleukin-1 receptor, type I

IL1R1 分子靶点综述

白细胞介素1受体I型（IL-1R1），又称分化簇121a（CD121a），是一种白细胞介素受体。该蛋白属于白细胞介素1受体家族，能够与白细胞介素α（IL-1α）、白细胞介素β（IL-1β）以及白细胞介素1受体拮抗剂（IL-1RA）结合。作为细胞因子受体的重要成员，IL-1R1/CD121a在多种细胞因子介导的免疫和炎症反应中发挥关键作用。
通过药理学和分子生物学技术研究发现，小鼠脑组织中存在该受体的表达。当神经组织受损时，梭形星形胶质细胞会包裹伤口区，将健康组织与受损区域分隔。这一形态改变及后续修复过程依赖于IL-1β通过IL-1R1受体介导的信号传导——联合应用IL-1受体拮抗蛋白（IL-1ra）可完全阻断IL-1β的效应。

IL1R1, interleukin 1 receptor type 1 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human IL1R1 分子靶点信息

  • 分子名：IL1R1, interleukin 1 receptor type 1
  • 别称：
    • antigen CD121a
    • CD121 antigen-like family member A
    • CD121A
    • CRMO3
    • D2S1473
    • IL-1R-1
    • IL-1R-alpha
    • IL-1RT-1
    • IL-1RT1
    • IL1R
    • IL1RA
    • interleukin 1 receptor alpha, type I
    • interleukin 1 receptor, type I
    • interleukin receptor 1
    • interleukin-1 receptor alpha
    • interleukin-1 receptor type 1
    • interleukin-1 receptor type I
    • P80
  • 基因序列：NCBI_Gene: 3554
  • 蛋白序列：UniProtKB: P14778

人 Human IL1R1靶点分子功能（预测）

Enables interleukin-1 receptor activity and platelet-derived growth factor receptor binding activity. Involved in interleukin-1-mediated signaling pathway; positive regulation of cytokine production; and positive regulation of signal transduction. Located in membrane. Is active in plasma membrane. Implicated in chronic recurrent multifocal osteomyelitis; systemic scleroderma; and type 1 diabetes mellitus. Biomarker of COVID-19; cholesteatoma of middle ear; and severe acute respiratory syndrome.

小鼠 Mouse Il1r1 分子靶点信息

小鼠 Mouse Il1r1 靶点分子功能（预测）

Enables interleukin-1 binding activity; interleukin-1 receptor activity; and protease binding activity. Involved in interleukin-1-mediated signaling pathway. Acts upstream of or within several processes, including cytokine-mediated signaling pathway; positive regulation of interleukin-1-mediated signaling pathway; and positive regulation of neutrophil extravasation. Located in external side of plasma membrane. Is expressed in aorta-gonad-mesonephros; brain; liver; spleen; and uterus. Used to study Sjogren's syndrome and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in chronic recurrent multifocal osteomyelitis; systemic scleroderma; and type 1 diabetes mellitus. Orthologous to human IL1R1 (interleukin 1 receptor type 1).

大鼠 Rat Il1r1 分子靶点信息

  • 分子名：Il1r1, interleukin 1 receptor, type I
  • 别称：
    • CD121 antigen-like family member A
    • IL-1R-1
    • IL-1R-alpha
    • IL-1RT-1
    • IL-1RT1
    • interleukin 1 beta receptor type 1 short transmembrane form
    • interleukin 1 beta receptor type 1 soluble form
    • interleukin 1 bete receptor type 1 long transmembrane form
    • interleukin 1 receptor, type I
    • interleukin-1 receptor alpha
    • interleukin-1 receptor type 1
    • interleukin-1 receptor type I
    • p80
  • 基因序列：NCBI_Gene: 25663
  • 蛋白序列：UniProtKB: Q02955

大鼠 Rat Il1r1 靶点分子功能（预测）

Enables ionotropic glutamate receptor binding activity. Involved in several processes, including interleukin-1-mediated signaling pathway; positive regulation of neuron migration; and response to odorant. Located in axon; cell surface; and extracellular space. Part of protein-containing complex. Biomarker of pulpitis. Human ortholog(s) of this gene implicated in chronic recurrent multifocal osteomyelitis; systemic scleroderma; and type 1 diabetes mellitus. Orthologous to human IL1R1 (interleukin 1 receptor type 1).

IL1R1 分子产品列表

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