文章目录[隐藏]
IGFBP7 分子靶点信息概述
- 分子名：IGFBP7, insulin like growth factor binding protein 7
- 基因家族：I-set domain containing
- 别名：MAC25; IGFBP-7; PSF; FSTL2
- 全称：insulin-like growth factor binding protein 7
IGFBP7 分子靶点综述
胰岛素样生长因子（IGF）结合蛋白的超家族包括六个高亲和力IGF结合蛋白（IGFBP）和至少四个其他低亲和力结合蛋白，称为IGFBP相关蛋白（IGFBP-rP）。IGFBP7是一种低亲和力的IGF结合蛋白，在调节多种细胞类型（包括刺激前列环素产生和细胞黏附）中的胰岛素样生长因子（IGF）作用中起着不可或缺的作用 。一些IGFBP也可能具有固有的生物活性，这与其结合IGF蛋白的能力无关。IGFBP7水平与癌症的发展有关。 IGFBP7表达的丧失与多种癌症类型的不良存活率和肿瘤化疗耐药性有关。 IGFBP7也已被确定为人类急性肾损伤的细胞周期停滞生物标志物，并作为早期急性肾损伤发展的预后指标。
IGFBP7, insulin like growth factor binding protein 7 分子靶点种属信息
人 Human IGFBP7 分子靶点信息
- 分子名：IGFBP7, insulin like growth factor binding protein 7
- 别称：
- AGM
- angiomodulin
- FSTL2
- IBP-7
- IGF-binding protein 7
- IGFBP-7
- IGFBP-7v
- IGFBP-rP1
- IGFBPRP1
- insulin-like growth factor binding protein 7
- insulin-like growth factor-binding protein 7
- MAC25
- PGI2-stimulating factor
- prostacyclin-stimulating factor
- PSF
- RAMSVPS
- TAF
- tumor-derived adhesion factor
- 基因序列：NCBI_Gene: 3490
- 蛋白序列：UniProtKB: Q16270
人 Human IGFBP7靶点分子功能（预测）
Predicted to enable insulin-like growth factor binding activity. Predicted to be an extracellular matrix structural constituent. Involved in cell adhesion. Located in extracellular exosome. Colocalizes with collagen-containing extracellular matrix.
小鼠 Mouse Igfbp7 分子靶点信息
- 分子名：Igfbp7, insulin-like growth factor binding protein 7
- 别称：
- AGM
- follistatin-like 2
- Fstl2
- mac25
- 基因序列：NCBI_Gene: 29817
- 蛋白序列：
小鼠 Mouse Igfbp7 靶点分子功能（预测）
Predicted to enable insulin-like growth factor binding activity. Predicted to be an extracellular matrix structural constituent. Acts upstream of or within inner ear development. Located in collagen-containing extracellular matrix and extracellular space. Is expressed in several structures, including alimentary system; brain; cardiovascular system; eye; and genitourinary system. Orthologous to human IGFBP7 (insulin like growth factor binding protein 7).
大鼠 Rat Igfbp7 分子靶点信息
- 分子名：Igfbp7, insulin-like growth factor binding protein 7
- 别称：
- insulin-like growth factor-binding protein 7
- LOC289560
- 基因序列：NCBI_Gene: 289560
- 蛋白序列：
大鼠 Rat Igfbp7 靶点分子功能（预测）
Predicted to enable insulin-like growth factor binding activity. Involved in several processes, including embryo implantation; response to cortisol; and response to retinoic acid. Located in extracellular space. Biomarker of renal cell carcinoma. Orthologous to human IGFBP7 (insulin like growth factor binding protein 7).
