IGFBP6 靶点信息

IGFBP6 分子靶点信息概述

  • 分子名：IGFBP6, insulin like growth factor binding protein 6
  • 基因家族：Insulin like growth factor binding proteins
  • 全称：insulin-like growth factor binding protein 6

IGFBP6 分子靶点综述

胰岛素样生长因子(IGF)结合蛋白超家族包括六种高亲和力IGF结合蛋白(IGFBP)和至少四种被称为IGFBP相关蛋白(IGFBP-rP)的低亲和力结合蛋白。所有IGFBP超家族成员都是富含半胱氨酸的蛋白质，具有保守的半胱氨酸残基。IGFBPs有助于延长所有组织(包括前列腺)中IGF的半衰期。在人类中，胰岛素样生长因子结合蛋白6(IGFBP-6)是一个由IGFBP6基因编码的蛋白质。IGFBP-6结合IGF-II比IGF-I具有更高的亲和力，且它是IGF-II特异性的抑制剂。据报道，IGFBP-6不依赖于IGF，在细胞增殖、存活、分化和迁移中发挥作用。IGFBP-6由于其明显的IGF-II结合偏好，在IGFBPs中是独一无二的。

IGFBP6, insulin like growth factor binding protein 6 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human IGFBP6 分子靶点信息

  • 分子名：IGFBP6, insulin like growth factor binding protein 6
  • 别称：
    • IBP-6
    • IBP6
    • IGF binding protein 6
    • IGF-binding protein 6
    • IGFBP-6
    • insulin-like growth factor binding protein 6
    • insulin-like growth factor-binding protein 6
  • 基因序列：NCBI_Gene: 3489
  • 蛋白序列：UniProtKB: P24592

人 Human IGFBP6靶点分子功能（预测）

Enables identical protein binding activity and insulin-like growth factor II binding activity. Involved in cell migration and positive regulation of stress-activated MAPK cascade. Part of insulin-like growth factor binary complex. Implicated in obesity. Biomarker of breast cancer; in situ carcinoma; leiomyoma; and neovascular inflammatory vitreoretinopathy.

小鼠 Mouse Igfbp6 分子靶点信息

小鼠 Mouse Igfbp6 靶点分子功能（预测）

Predicted to enable fibronectin binding activity; identical protein binding activity; and insulin-like growth factor binding activity. Predicted to be involved in cell migration; positive regulation of stress-activated MAPK cascade; and regulation of insulin-like growth factor receptor signaling pathway. Located in collagen-containing extracellular matrix and extracellular space. Is expressed in several structures, including blastocyst; compacted morula; genitourinary system; liver; and spleen. Human ortholog(s) of this gene implicated in obesity. Orthologous to human IGFBP6 (insulin like growth factor binding protein 6).

大鼠 Rat Igfbp6 分子靶点信息

  • 分子名：Igfbp6, insulin-like growth factor binding protein 6
  • 别称：
    • IBP-6
    • IGF-binding protein 6
    • IGF-BP6
    • IGFBP-6
    • insulin-like growth factor-binding protein 6
    • RBP6A
    • RBP6G
  • 基因序列：NCBI_Gene: 25641
  • 蛋白序列：UniProtKB: P35572

大鼠 Rat Igfbp6 靶点分子功能（预测）

Enables insulin-like growth factor I binding activity and insulin-like growth factor II binding activity. Predicted to be involved in cell migration; positive regulation of stress-activated MAPK cascade; and regulation of insulin-like growth factor receptor signaling pathway. Located in Golgi apparatus and extracellular space. Human ortholog(s) of this gene implicated in obesity. Orthologous to human IGFBP6 (insulin like growth factor binding protein 6).

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