HSPB1 靶点信息

HSPB1 分子靶点信息概述

  • 分子名：HSPB1, heat shock protein family B (small) member 1
  • 基因家族：Small heat shock proteins
  • 别名：HSP27; HSP28; Hs.76067; Hsp25; CMT2F
  • 全称：heat shock 27kD protein 1; heat shock 27kDa protein 1

HSPB1 分子靶点综述

热休克蛋白(HSP)是一组高度保守的应激蛋白，主要功能是作为分子伴侣，并参与多种生物学过程包括耐热性、抑制细胞凋亡、调节细胞发育和细胞分化、以及信号转导。 HSP27，又名HSPB1，是小分子热休克蛋白组中的分子伴侣。它存在于许多细胞类型中，尤其是所有类型的肌细胞，在细胞分化和发育的不同阶段过度表达。HSP27参与细胞凋亡信号途径，抑制procaspase-9的活化。此外，HSP27可保护肌动蛋白丝免受破碎，还可激活蛋白酶。HSP27可能是一个潜在的诊断标志物，高水平的HSP27存在于乳腺癌患者的血清中。磷酸化的HSP27增加人类前列腺癌细胞的浸润、促进细胞增殖并抑制Fas诱导的细胞凋亡。

HSPB1, heat shock protein family B (small) member 1 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human HSPB1 分子靶点信息

  • 分子名：HSPB1, heat shock protein family B (small) member 1
  • 别称：
    • 28 kDa heat shock protein
    • CMT2F
    • DKFZp586P1322
    • epididymis secretory protein Li 102
    • estrogen-regulated 24 kDa protein
    • heat shock 27 kDa protein
    • heat shock 27kD protein 1
    • heat shock 27kDa protein 1
    • heat shock protein beta-1
    • HEL-S-102
    • HMN2B
    • HS.76067
    • HSP 27
    • Hsp25
    • HSP27
    • HSP28
    • putative heat shock protein family B member 1 isoform
    • SRP27
    • stress-responsive protein 27
  • 基因序列：NCBI_Gene: 3315
  • 蛋白序列：UniProtKB: P04792

人 Human HSPB1靶点分子功能（预测）

Enables several functions, including protein folding chaperone; protein homodimerization activity; and protein kinase binding activity. Involved in several processes, including anterograde axonal protein transport; positive regulation of angiogenesis; and positive regulation of endothelial cell migration. Located in cytoplasm and nucleus. Implicated in Charcot-Marie-Tooth disease axonal type 2F; distal hereditary motor neuropathy type 2B; pancreatic cancer; and sarcoma. Biomarker of focal segmental glomerulosclerosis and rheumatoid arthritis.

小鼠 Mouse Hspb1 分子靶点信息

小鼠 Mouse Hspb1 靶点分子功能（预测）

Enables protein kinase C binding activity and protein kinase C inhibitor activity. Involved in negative regulation of protein kinase activity; positive regulation of cytokine production; and regulation of intracellular signal transduction. Acts upstream of or within negative regulation of apoptotic signaling pathway. Located in Z disc; nucleus; and plasma membrane. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and heart. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2F; distal hereditary motor neuropathy type 2B; pancreatic cancer; and sarcoma. Orthologous to human HSPB1 (heat shock protein family B (small) member 1).

大鼠 Rat Hspb1 分子靶点信息

  • 分子名：Hspb1, heat shock protein family B (small) member 1
  • 别称：
    • heat shock 27 kDa protein
    • heat shock 27 kDa protein 1
    • heat shock 27kDa protein 1
    • heat shock protein 1
    • heat shock protein B1
    • heat shock protein beta-1
    • HSP 27
    • Hsp25
    • Hsp27
  • 基因序列：NCBI_Gene: 24471
  • 蛋白序列：

大鼠 Rat Hspb1 靶点分子功能（预测）

Enables ubiquitin binding activity. Involved in several processes, including cellular response to butyrate; cellular response to interleukin-11; and response to ischemia. Located in several cellular components, including myofibril; perikaryon; and postsynaptic density membrane. Part of proteasome complex. Biomarker of Alzheimer's disease and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2F; distal hereditary motor neuropathy type 2B; pancreatic cancer; and sarcoma. Orthologous to human HSPB1 (heat shock protein family B (small) member 1).

HSPB1 分子产品列表

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