FGFR3 靶点信息

FGFR3 分子靶点信息概述

  • 分子名：FGFR3, fibroblast growth factor receptor 3
  • 基因家族：I-set domain containing; Receptor tyrosine kinases; CD molecules
  • 别名：CEK2; JTK4; CD333
  • 曾用名：ACH
  • 全称：achondroplasia, thanatophoric dwarfism

FGFR3 分子靶点综述

成纤维细胞生长因子受体3（FGFR3），又称CD333，是成纤维细胞生长因子受体（FGFR）家族成员，其氨基酸序列在家族成员间及不同物种间高度保守。FGFR家族成员在配体亲和性和组织分布上存在差异。FGFRs是具有细胞内酪氨酸激酶活性的跨膜催化受体。FGFR基因突变可导致多种以骨骼发育异常（如软骨发育不全）为特征的人类发育障碍，而FGFR表达上调可能导致细胞转化和癌症。
FGFR3作为全长代表性蛋白，其结构包含：由三个免疫球蛋白样结构域组成的胞外区、单个疏水性跨膜片段和胞内酪氨酸激酶结构域。FGFR3的胞外部分与成纤维细胞生长因子相互作用，启动下游信号级联反应，最终影响细胞有丝分裂和分化。FGFR3既能结合酸性也能结合碱性成纤维细胞生长激素，在骨骼发育和维持中发挥重要作用。FGFR3基因突变会导致颅缝早闭和多种类型的骨骼发育不良。目前已发现三种编码不同蛋白亚型的可变剪接转录变体。CD333是酸性和碱性成纤维细胞生长因子的受体。

FGFR3, fibroblast growth factor receptor 3 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human FGFR3 分子靶点信息

  • 分子名：IFNG, interferon gamma
  • 别称：
    • ACH
    • achondroplasia, thanatophoric dwarfism
    • CD333
    • CEK2
    • FGFR-3
    • fibroblast growth factor receptor 3 variant 4
    • fibroblast growth factor receptor 3-S
    • HSFGFR3EX
    • hydroxyaryl-protein kinase
    • JTK4
    • tyrosine kinase JTK4
  • 基因序列：NCBI_Gene: 2261
  • 蛋白序列：UniProtKB: P22607

人 Human FGFR3 靶点分子功能（预测）

Enables fibroblast growth factor binding activity; fibroblast growth factor receptor activity; and identical protein binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of intracellular signal transduction; and positive regulation of tyrosine phosphorylation of STAT protein. Located in several cellular components, including Golgi apparatus; endoplasmic reticulum; and transport vesicle. Implicated in several diseases, including Human papillomavirus infectious disease; SADDAN; acanthosis nigricans; bone disease (multiple); and carcinoma (multiple). Biomarker of several diseases, including Merkel cell carcinoma; chronic myeloid leukemia; gastrointestinal system cancer (multiple); thanatophoric dysplasia; and urinary bladder cancer (multiple).

小鼠 Mouse Fgfr3 分子靶点信息

小鼠 Mouse Fgfr3 靶点分子功能（预测）

Enables fibroblast growth factor receptor activity and miRNA binding activity. Involved in several processes, including bone development; post-anal tail morphogenesis; and response to sodium phosphate. Acts upstream of or within several processes, including epithelial cell differentiation; negative regulation of cell differentiation; and nervous system development. Located in cytoplasmic side of plasma membrane; lysosome; and perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; brain; respiratory system; sensory organ; and skeleton. Used to study Muenke Syndrome; achondroplasia; hypochondroplasia; scoliosis; and thanatophoric dysplasia. Human ortholog(s) of this gene implicated in several diseases, including Human papillomavirus infectious disease; SADDAN; acanthosis nigricans; bone disease (multiple); and carcinoma (multiple). Orthologous to human FGFR3 (fibroblast growth factor receptor 3).

大鼠 Rat Fgfr3 分子靶点信息

大鼠 Rat Fgfr3 靶点分子功能（预测）

Enables fibroblast growth factor binding activity and fibroblast growth factor receptor activity. Involved in cell-cell signaling; fibroblast growth factor receptor signaling pathway; and positive regulation of cell population proliferation. Located in cell surface. Biomarker of chondrosarcoma. Human ortholog(s) of this gene implicated in several diseases, including Human papillomavirus infectious disease; SADDAN; acanthosis nigricans; bone disease (multiple); and carcinoma (multiple). Orthologous to human FGFR3 (fibroblast growth factor receptor 3).

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