F7 靶点信息

F7 分子靶点信息概述

  • 分子名：F7, coagulation factor VII
  • 基因家族：Gla domain containing
  • 别名：eptacog alfa; FVII coagulation protein; factor VII
  • 曾用名：coagulation factor VII (serum prothrombin conversion accelerator)

F7 分子靶点综述

凝血因子VII（Coagulation factor VII），又称血清凝血酶原转化加速因子（Serum prothrombin conversion accelerator）、F7或FVII，是肽酶S1家族的成员。作为凝血级联反应的核心蛋白之一，它属于丝氨酸蛋白酶类酶，且凝血因子VII（FVII）缺乏症是最常见的罕见先天性出血性疾病。凝血因子VII包含两个EGF样结构域、一个Gla（γ-羧基谷氨酸）结构域和一个肽酶S1结构域。其主要作用是与组织因子（TF）共同启动凝血过程。组织因子位于血管外侧，通常不与血流接触。凝血因子VII的作用会受到组织因子途径抑制物（TFPI）的阻碍，后者在凝血启动后几乎立即释放。凝血因子VII依赖维生素K并在肝脏中合成。当血管受损时，组织因子暴露于血液和循环中的凝血因子VII。一旦与TF结合，FVII会被不同的蛋白酶激活为FVIIa，这些蛋白酶包括凝血酶（因子IIa）、因子Xa、IXa、XIIa以及FVIIa-TF复合物本身。

F7, coagulation factor VII 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human F7 分子靶点信息

  • 分子名：F7, coagulation factor VII
  • 别称：
    • coagulation factor VII (serum prothrombin conversion accelerator)
    • eptacog alfa
    • FVII coagulation protein
    • FVIIa
    • proconvertin
    • serum prothrombin conversion accelerator
    • SPCA
  • 基因序列：NCBI_Gene: 2155
  • 蛋白序列：UniProtKB: P08709

人 Human F7 靶点分子功能（预测）

Contributes to serine-type endopeptidase activity. Involved in several processes, including blood coagulation; positive regulation of chemotaxis; and positive regulation of signal transduction. Located in collagen-containing extracellular matrix. Part of serine-type peptidase complex. Implicated in several diseases, including artery disease (multiple); cerebral infarction; diabetes mellitus (multiple); factor VII deficiency; and obesity. Biomarker of several diseases, including angioedema (multiple); artery disease (multiple); diabetic neuropathy; glucose metabolism disease (multiple); and kidney disease (multiple).

小鼠 Mouse F7 分子靶点信息

小鼠 Mouse F7 靶点分子功能（预测）

Predicted to enable serine-type endopeptidase activity and signaling receptor binding activity. Acts upstream of or within blood coagulation. Predicted to be located in vesicle. Predicted to be part of serine-type peptidase complex. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebral infarction; diabetes mellitus (multiple); factor VII deficiency; and obesity. Orthologous to human F7 (coagulation factor VII).

大鼠 Rat F7 分子靶点信息

  • 分子名：F7, coagulation factor VII
  • 别称：
    • coagulation factor VII (serum prothrombin conversion accelerator)
    • serum prothrombin conversion accelerator
  • 基因序列：NCBI_Gene: 260320
  • 蛋白序列：

大鼠 Rat F7 靶点分子功能（预测）

Enables endopeptidase activity and signaling receptor binding activity. Involved in several processes, including response to growth hormone; response to thyrotropin-releasing hormone; and response to thyroxine. Located in extracellular space and vesicle. Used to study asthma; diabetes mellitus; and type 2 diabetes mellitus. Biomarker of several diseases, including bilirubin metabolic disorder; familial hyperlipidemia; hypertension; hypothyroidism; and prothrombin deficiency. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebral infarction; diabetes mellitus (multiple); factor VII deficiency; and obesity. Orthologous to human F7 (coagulation factor VII).

F7 分子产品列表

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