DPP4 靶点信息

DPP4 分子靶点信息概述

  • 分子名：DPP4, dipeptidyl peptidase 4
  • 基因家族：CD molecules; DASH family
  • 别名：DPPIV
  • 曾用名：CD26; ADCP2
  • 全称：dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2); adenosine deaminase complexing protein 2; dipeptidyl-peptidase 4

DPP4 分子靶点综述

二肽基多肽酶IV(DPPIV)，又名腺苷脱氨酶复合蛋白2或CD26，是一种在大多数细胞类型表面表达的抗原酶，与免疫调节、信号转导和细胞凋亡相关。它是一种先天性膜糖蛋白和丝氨酸外肽酶。DPPIV在葡萄糖代谢中起重要作用，负责肠促胰岛素如GLP-1的降解。此外，它还可抑制癌症和肿瘤的发展。动物实验表明它在许多器官如肝和肾的纤维化发展中发挥其致病作用。DPPIV在肿瘤生物学中起重要作用，是多种癌症的有效标志物，其水平在一些肿瘤的细胞表面或血清中升高、在其它肿瘤中降低。中东呼吸综合征冠状病毒，一个新的与SARS相关的冠状病毒，研究发现其可结合DPPIV。DPPIV存在于气道(如肺)和肾脏的细胞表面，科学家利用它们的这一优势来阻断病毒进入细胞。

DPP4, dipeptidyl peptidase 4 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human DPP4 分子靶点信息

  • 分子名：DPP4, dipeptidyl peptidase 4
  • 别称：
    • ADABP
    • ADCP-2
    • ADCP2
    • adenosine deaminase complexing protein 2
    • CD26
    • dipeptidyl peptidase IV
    • dipeptidyl-peptidase 4
    • dipeptidyl-peptidase 4 (CD26, adenosine deaminase complexing protein 2)
    • dipeptidylpeptidase 4
    • dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2)
    • DPP IV
    • DPPIV
    • Gly-Pro naphthylamidase
    • Post-proline dipeptidyl aminopeptidase IV
    • T-cell activation antigen CD26
    • TP103
    • Xaa-Pro-dipeptidylaminopeptidase
  • 基因序列：NCBI_Gene: 1803
  • 蛋白序列：UniProtKB: P27487

人 Human DPP4靶点分子功能（预测）

Enables several functions, including chemorepellent activity; peptidase activity; and protein homodimerization activity. Involved in several processes, including negative regulation of extracellular matrix disassembly; negative regulation of neutrophil chemotaxis; and regulation of cell-cell adhesion. Located in several cellular components, including apical plasma membrane; endocytic vesicle; and lamellipodium. Implicated in Middle East respiratory syndrome and type 2 diabetes mellitus.

小鼠 Mouse Dpp4 分子靶点信息

小鼠 Mouse Dpp4 靶点分子功能（预测）

Predicted to enable several functions, including chemorepellent activity; peptidase activity; and protein homodimerization activity. Acts upstream of or within behavioral fear response; locomotory exploration behavior; and psychomotor behavior. Located in intercellular canaliculus. Is expressed in several structures, including genitourinary system; inner ear; intraembryonic coelom; liver; and primitive heart tube. Used to study Middle East respiratory syndrome. Human ortholog(s) of this gene implicated in Middle East respiratory syndrome and type 2 diabetes mellitus. Orthologous to human DPP4 (dipeptidyl peptidase 4).

大鼠 Rat Dpp4 分子靶点信息

大鼠 Rat Dpp4 靶点分子功能（预测）

Enables several functions, including collagen binding activity; dipeptidyl-peptidase activity; and identical protein binding activity. Involved in several processes, including B-1a B cell differentiation; proteolysis; and regulation of lymphocyte mediated immunity. Located in several cellular components, including Golgi apparatus; cell surface; and endoplasmic reticulum. Human ortholog(s) of this gene implicated in Middle East respiratory syndrome and type 2 diabetes mellitus. Orthologous to human DPP4 (dipeptidyl peptidase 4).

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