DLL1 靶点信息

DLL1 分子靶点信息概述

  • 分子名：DLL1, delta like canonical Notch ligand 1
  • 别名：delta (Drosophila)-like 1; delta-like 1 (Drosophila)

DLL1 分子靶点综述

DLL1 (Delta-like protein 1，δ样蛋白1)是Notch配体的跨膜糖蛋白。它在中枢神经系统的形态发生、椎间关节的形成、内耳毛细胞的发育和形成以及动脉的形成中起重要作用。DLL1 参与调节神经、胰腺和肌原祖细胞、T淋巴细胞和B淋巴细胞的稳态和分化。DLL1在许多癌症中过表达，与肿瘤的发生相关。DLL1的胞外区域可以从细胞表面脱落，胞内结构域可以被γ-分泌酶剪切，转移到细胞核，进而调控基因转录。

DLL1, delta like canonical Notch ligand 1 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human DLL1 分子靶点信息

  • 分子名：DLL1, delta like canonical Notch ligand 1
  • 别称：
    • Delta
    • delta-like 1 (Drosophila)
    • delta-like 1 protein
    • delta-like protein 1
    • DELTA1
    • DL1
    • drosophila Delta homolog 1
    • H-Delta-1
    • NEDBAS
  • 基因序列：NCBI_Gene: 28514
  • 蛋白序列：UniProtKB: O00548

人 Human DLL1靶点分子功能（预测）

Enables Notch binding activity and Tat protein binding activity. Involved in Notch signaling pathway; negative regulation of interleukin-10 production; and neuronal stem cell population maintenance. Predicted to be located in adherens junction; apical plasma membrane; and membrane raft. Predicted to be active in plasma membrane. Biomarker of temporal arteritis.

小鼠 Mouse Dll1 分子靶点信息

小鼠 Mouse Dll1 靶点分子功能（预测）

Enables Notch binding activity and scaffold protein binding activity. Involved in several processes, including epithelial cell differentiation; negative regulation of cell differentiation; and nervous system development. Acts upstream of or within several processes, including anterior/posterior pattern specification; negative regulation of cell differentiation; and nephron tubule development. Located in several cellular components, including adherens junction; apical plasma membrane; and membrane raft. Is expressed in several structures, including alimentary system; central nervous system; limb; metanephros; and sensory organ. Orthologous to human DLL1 (delta like canonical Notch ligand 1).

大鼠 Rat Dll1 分子靶点信息

  • 分子名：Dll1, delta like canonical Notch ligand 1
  • 别称：
    • delta (Drosophila)-like 1
    • delta-like 1 (Drosophila)
    • delta-like protein 1
    • delta1
    • drosophila Delta homolog 1
  • 基因序列：NCBI_Gene: 84010
  • 蛋白序列：

大鼠 Rat Dll1 靶点分子功能（预测）

Enables Notch binding activity. Involved in clathrin-dependent endocytosis and positive regulation of Notch signaling pathway. Predicted to be located in several cellular components, including adherens junction; apical plasma membrane; and membrane raft. Predicted to be active in plasma membrane. Orthologous to human DLL1 (delta like canonical Notch ligand 1).

DLL1 分子产品列表

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