文章目录[隐藏]
CD8A 分子靶点信息概述
- 分子名：CD8A, CD8a molecule
- 基因家族：CD molecules; V-set domain containing
- 曾用名：CD8
- 全称：CD8 antigen, alpha polypeptide (p32); T-cell surface glycoprotein CD8 alpha chain
CD8A 分子靶点综述
CD8也称为T8或Leu2，是免疫球蛋白超家族的一员，表达于大部分胸腺细胞、外周血T细胞亚群和NK细胞(基本为CD8α/α同源二聚体)。CD8在抗原识别和T细胞活化中，作为MHC I类分子受限的T细胞受体，并在胸腺分化中具有重要作用。
CD8A, CD8a molecule 分子靶点种属信息
人 Human CD8A 分子靶点信息
- 分子名：CD8A, CD8a molecule
- 别称：
- CD8
- cd8 antigen, alpha chain
- CD8 antigen, alpha polypeptide (p32)
- Cluster of Differentiation 8a
- Leu2
- Leu2 T-lymphocyte antigen
- MAL
- OKT8 T-cell antigen
- p32
- T cell co-receptor
- T-cell antigen Leu2
- T-cell surface glycoprotein CD8 alpha chain
- T-lymphocyte differentiation antigen T8/Leu-2
- T8 T-cell antigen
- 基因序列：NCBI_Gene: 925
- 蛋白序列：UniProtKB: P01732
人 Human CD8A靶点分子功能（预测）
Enables MHC class I protein complex binding activity. Predicted to be involved in T cell mediated immunity; cell surface receptor signaling pathway; and cytotoxic T cell differentiation. Predicted to act upstream of or within defense response to virus and positive regulation of calcium-mediated signaling. Located in external side of plasma membrane and plasma membrane raft. Biomarker of COVID-19; erythema multiforme; and stomach cancer.
小鼠 Mouse Cd8a 分子靶点信息
- 分子名：Cd8a, CD8 antigen, alpha chain
- 别称：
- BB154331
- expressed sequence BB154331
- Ly-2
- Ly-35
- Ly-B
- lymphocyte antigen 2
- lymphocyte antigen 35
- Lyt-2
- T-lymphocyte antigen 2
- 基因序列：NCBI_Gene: 12525
- 蛋白序列：
小鼠 Mouse Cd8a 靶点分子功能（预测）
Enables identical protein binding activity. Acts upstream of or within several processes, including cytotoxic T cell differentiation; defense response to virus; and positive regulation of calcium-mediated signaling. Located in external side of plasma membrane. Is expressed in several structures, including endocrine gland; exocrine gland; genitourinary system; gut; and hemolymphoid system gland. Orthologous to human CD8A (CD8a molecule).
大鼠 Rat Cd8a 分子靶点信息
- 分子名：Cd8a, CD8a molecule
- 别称：
- CD8 antigen 32 kDa chain
- CD8 antigen alpha-chain
- CD8 antigen, alpha chain
- CD8 antigen, alpha-chain
- OX-8 membrane antigen
- T-cell surface glycoprotein CD8 alpha chain
- 基因序列：NCBI_Gene: 24930
- 蛋白序列：UniProtKB: P07725
大鼠 Rat Cd8a 靶点分子功能（预测）
Enables protein kinase binding activity. Involved in T cell activation. Predicted to be located in cell surface and plasma membrane raft. Predicted to be active in external side of plasma membrane. Orthologous to human CD8A (CD8a molecule).
