CD163 靶点信息

CD163 分子靶点信息概述

  • 分子名：CD163, CD163 molecule
  • 基因家族：CD molecules; Scavenger receptors; Scavenger receptor cysteine rich domain containing
  • 别名：M130; MM130; SCARI1
  • 全称：CD163 antigen

CD163 分子靶点综述

CD163是一种蛋白质，在人类中由CD163基因编码。它属于富含半胱氨酸的B型清道夫受体家族，包含一个1048个氨基酸残基组成的胞外结构域、一个单次跨膜片段和一个带有几个剪接变异的胞质尾区。它是血红蛋白-结合珠蛋白复合物的清道夫受体，可标记单核细胞/巨噬细胞谱系。该受体的可溶性形式存在于血浆中，通常表示为sCD163。sCD163是由膜结合受体的胞外域脱落产生，在大范围的炎症性疾病包括肝硬化、2型糖尿病、巨噬细胞活化综合征、高雪氏病、败血症、HIV感染、类风湿性关节炎和霍奇金淋巴瘤中上调。

CD163, CD163 molecule 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human CD163 分子靶点信息

  • 分子名：CD163, CD163 molecule
  • 别称：
    • cluster of differentiation 163
    • hemoglobin scavenger receptor
    • M130
    • macrophage-associated antigen
    • MM130
    • SCARI1
    • scavenger receptor cysteine-rich type 1 protein M130
  • 基因序列：NCBI_Gene: 9332
  • 蛋白序列：UniProtKB: Q86VB7

人 Human CD163靶点分子功能（预测）

Enables scaffold protein binding activity. Predicted to be involved in acute-phase response and endocytosis. Located in external side of plasma membrane. Biomarker of several diseases, including Ebola hemorrhagic fever; Whipple disease; fatty liver disease (multiple); leishmaniasis (multiple); and lung disease (multiple).

小鼠 Mouse Cd163 分子靶点信息

小鼠 Mouse Cd163 靶点分子功能（预测）

Predicted to enable scaffold protein binding activity and scavenger receptor activity. Predicted to act upstream of or within acute-phase response. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including gut; immune system; male reproductive gland or organ; olfactory lobe; and quadriceps femoris muscle. Orthologous to human CD163 (CD163 molecule).

大鼠 Rat Cd163 分子靶点信息

大鼠 Rat Cd163 靶点分子功能（预测）

Predicted to enable scaffold protein binding activity. Predicted to be involved in endocytosis. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Biomarker of uveitis. Orthologous to human CD163 (CD163 molecule).

CD163 分子产品列表

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