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CCR7/BLR2/CD197 分子靶点信息概述
- 分子名：CCR7, C-C motif chemokine receptor 7
- 别名：CMKBR7; EBI1; BLR2; CDw197; CD197
- 全称：chemokine (C-C motif) receptor 7
CCR7/BLR2/CD197 分子靶点综述
CD197(CCR7)是G蛋白偶联受体家族的成员，是趋化因子的一个亚家族。CCR7被鉴定为是由EB病毒（EBV）诱导的，被认为是EBV对B淋巴细胞作用的介体。据报道，CCR7在血液、骨髓、淋巴结和肠道中表达。CCR7尤其在淋巴组织和活化的B和T淋巴细胞中表达，并已被证明控制记忆T细胞向炎症组织的迁移和刺激树突状细胞成熟。据报道，趋化因子（C-C基序）配体19（CCL19/ECL）是该受体的特异性配体。EST已从血液、胚胎、淋巴结和胸腺文库中分离出来。C-C趋化因子家族的受体包括CCR1、CCR2A、CCR3、CCR4、CCR5和达菲血型抗原。
CCR7, C-C motif chemokine receptor 7 分子靶点种属信息
人 Human CCR7/BLR2/CD197 分子靶点信息
- 分子名：CCR7, C-C motif chemokine receptor 7
- 别称：
- BLR2
- Bukitt's lymphoma receptor 2
- C-C chemokine receptor type 7
- C-C CKR-7
- CC chemokine receptor 7
- CC-CKR-7
- CCR-7
- CD197
- CDw197
- chemokine (C-C motif) receptor 7
- chemokine (C-C) receptor 7
- CMKBR7
- EBI1
- EBV-induced G protein-coupled receptor 1
- EBV-induced G-protein coupled receptor 1
- Epstein-Barr virus induced G-protein coupled receptor
- Epstein-Barr virus induced gene 1
- epstein-Barr virus-induced G-protein coupled receptor 1
- lymphocyte-specific G protein-coupled peptide receptor
- MIP-3 beta receptor
- 基因序列：NCBI_Gene: 1236
- 蛋白序列：UniProtKB: P32248
人 Human CCR7/BLR2/CD197 靶点分子功能（预测）
Enables C-C chemokine binding activity and C-C chemokine receptor activity. Involved in cellular response to cytokine stimulus; myeloid dendritic cell chemotaxis; and positive regulation of neutrophil chemotaxis. Located in cell surface; mitochondrion; and plasma membrane. Biomarker of pneumonia and pulmonary sarcoidosis.
小鼠 Mouse Ccr7/CD197 分子靶点信息
- 分子名：Ccr7, chemokine (C-C motif) receptor 7
- 别称：
- CD197
- chemokine (C-C) receptor 7
- Cmkbr7
- EBI1
- Ebi1h
- Epstein-Barr virus induced gene 1 homolog
- 基因序列：NCBI_Gene: 12775
- 蛋白序列：
小鼠 Mouse Ccr7/CD197 靶点分子功能（预测）
Enables C-C chemokine receptor activity. Involved in several processes, including positive regulation of immune response; positive regulation of leukocyte chemotaxis; and regulation of cytokine production. Acts upstream of or within chemotaxis; homeostasis of number of cells; and immune response. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; immune system; reproductive system; and white fat. Used to study Sjogren's syndrome. Orthologous to human CCR7 (C-C motif chemokine receptor 7).
大鼠 Rat Ccr7/CD197 分子靶点信息
- 分子名： Ccr7, C-C motif chemokine receptor 7
- 别称：
- C-C chemokine receptor type 7
- chemokine (C-C motif) receptor 7
- MGC108519
- 基因序列：NCBI_Gene: 287673
- 蛋白序列：
大鼠 Rat Ccr7/CD197 靶点分子功能（预测）
Predicted to enable C-C chemokine binding activity and C-C chemokine receptor activity. Predicted to be involved in several processes, including positive regulation of immune response; positive regulation of leukocyte chemotaxis; and regulation of cytokine production. Predicted to act upstream of or within several processes, including G protein-coupled receptor signaling pathway; chemokine-mediated signaling pathway; and homeostasis of number of cells. Predicted to be located in cell surface; mitochondrion; and plasma membrane. Predicted to be active in external side of plasma membrane. Orthologous to human CCR7 (C-C motif chemokine receptor 7).
